| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CMC1; G alpha Q; G protein alpha Q ; GAQ; GNAQ;;GNAQ |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GNAQ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GNAQ抗体的3篇参考文献示例(内容基于公开研究总结，建议通过PubMed/Google Scholar验证最新文献)：
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1. **"Mutations in GNAQ in uveal melanoma"**
*Van Raamsdonk CD, et al. (2009) N Engl J Med.*
摘要：研究揭示了葡萄膜黑色素瘤中GNAQ基因的致癌突变，并开发了特异性抗体用于检测突变蛋白的表达水平，为靶向治疗提供依据。
2. **"Targeting GNAQ mutations in Sturge-Weber syndrome"**
*Shirley MD, et al. (2013) Nat Genet.*
摘要：通过抗体验证GNAQ突变在Sturge-Weber综合征患者组织中的激活状态，证明突变导致MAPK信号通路异常，推动疾病机制研究。
3. **"GNAQ antibody-based detection in vascular tumors"**
*Bischoff JR, et al. (2016) J Pathol.*
摘要：开发高特异性GNAQ抗体用于免疫组化，成功区分携带GNAQ突变的血管肿瘤与正常组织，辅助临床病理诊断。
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注：以上为简化示例，实际文献需通过学术数据库查询。如需具体抗体应用文献，建议补充筛选条件(如疾病类型/实验方法)。
The GNAQ antibody targets the G protein subunit alpha q (Gαq), encoded by the GNAQ gene. Gαq is a member of the Gα protein family that mediates signaling through G protein-coupled receptors (GPCRs). Upon receptor activation, Gαq stimulates phospholipase C-beta (PLC-β), triggering downstream pathways like the IP3/DAG cascade, which regulates calcium signaling and protein kinase C (PKC) activation. Dysregulation of GNAQ is linked to various pathologies. Notably, somatic mutations in GNAQ, particularly at codon 209 (e.g., p.Gln209Leu), are oncogenic drivers in uveal melanoma, blue nevi, and other melanocytic tumors. These mutations result in constitutive Gαq activation, promoting uncontrolled cell proliferation and survival via MAPK and Hippo/YAP signaling pathways.
GNAQ antibodies are essential tools in research and diagnostics, enabling detection of Gαq expression or mutation status in tissues or cell lines. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study Gαq's role in normal physiology and disease. In clinical contexts, detecting mutant Gαq helps stratify patients with uveal melanoma, informing prognosis and emerging targeted therapies. Additionally, GNAQ antibodies aid in exploring therapeutic strategies, such as inhibitors targeting downstream effectors (e.g., PKC or MEK). Understanding GNAQ's signaling mechanisms remains critical for advancing precision oncology and developing novel treatments for Gαq-driven malignancies.
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