| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hKB; MAP3K16; MARK kinase; MARKK; PSK2; STE20 like kinase; Taok1;;TAOK1 |
| WB Predicted band size | 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TAOK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及TAOK1抗体的相关文献摘要信息(注：文献为示例性质，具体内容请以实际论文为准)：
1. **文献名称**: "TAOK1 phosphorylates Raptor to regulate stress-induced mTORC1 activation"
**作者**: Lee, G. et al.
**摘要**: 该研究利用TAOK1特异性抗体通过免疫沉淀和Western blot技术，揭示了TAOK1通过磷酸化mTORC1复合物中的Raptor蛋白，在细胞应激条件下调控mTOR信号通路的分子机制。
2. **文献名称**: "TAOK1 mediates neuronal apoptosis via interaction with MAPK signaling components"
**作者**: Zhang, Y. et al.
**摘要**: 通过TAOK1抗体进行免疫荧光染色和蛋白质组学分析，研究发现TAOK1在神经元中与JNK/p38通路相互作用，调控凋亡相关蛋白活性，为神经退行性疾病提供了潜在靶点。
3. **文献名称**: "Characterization of a novel TAOK1 monoclonal antibody for functional studies in cancer models"
**作者**: Thompson, R. et al.
**摘要**: 该文献报道了一种高特异性TAOK1单克隆抗体的开发与验证，通过体外和体内实验证明其可用于检测TAOK1在多种癌细胞系中的表达及亚细胞定位，并用于功能抑制研究。
4. **文献名称**: "TAOK1 deficiency impairs cortical development and leads to autistic-like behaviors in mice"
**作者**: Chen, L. et al.
**摘要**: 研究利用TAOK1敲除小鼠模型及抗体免疫组化技术，发现TAOK1缺失导致大脑皮层神经元迁移异常，并伴随自闭症样行为表型，提示其在神经发育中的关键作用。
(注：以上文献信息为模拟示例，实际引用请参考PubMed或学术数据库中的真实研究。)
TAOK1 (Thousand and One Amino Acid Kinase 1) is a serine/threonine kinase belonging to the STE20 family, known to regulate diverse cellular processes, including stress response, cell cycle progression, cytoskeletal dynamics, and apoptosis. It activates downstream MAPK pathways and modulates Hippo signaling, playing roles in development, neuronal function, and immune regulation. Dysregulation of TAOK1 has been implicated in cancers, neurodevelopmental disorders, and neurodegenerative diseases.
TAOK1 antibodies are essential tools for detecting and studying the expression, localization, and function of TAOK1 in biological samples. These antibodies are typically generated using immunogens derived from specific regions of the TAOK1 protein (e.g., N-terminal or catalytic domains) and validated for applications such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity.
Quality validation includes testing for cross-reactivity, specificity (e.g., using TAOK1-knockout controls), and performance in target experimental setups. Researchers use TAOK1 antibodies to explore its involvement in disease mechanisms, signaling crosstalk, and potential therapeutic targeting. Reliable antibodies are critical for elucidating TAOK1's roles in cellular homeostasis and pathology.
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