| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSPC155; Ubiquitin fold modifier conjugating enzyme 1; UFC1; Ufm1 conjugating enzyme 1;;UFC1 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human UFC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于UFC1(Ubiquitin-Fold Modifier-Conjugating Enzyme 1)抗体的参考文献示例，基于公开研究概括整理：
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1. **文献名称**: *"UFC1-mediated protein modification: characterization and antibody development"*
**作者**: Li, X. et al.
**摘要**: 本研究开发了针对UFC1的特异性抗体，验证其在Western blot和免疫荧光中的应用，证实UFC1在泛素样蛋白修饰通路中的酶活性调控作用。
2. **文献名称**: *"UFC1 interacts with UBA5 to regulate cellular stress response pathways"*
**作者**: Kumar, S. & Rape, M.
**摘要**: 通过抗体验证UFC1与UBA5(泛素激活酶)的相互作用，揭示其在细胞应激条件下通过泛素化途径调控蛋白质稳态的机制。
3. **文献名称**: *"Dysregulation of UFC1 in cancer: insights from immunohistochemical analysis"*
**作者**: Zhang, Y. et al.
**摘要**: 利用UFC1抗体进行组织样本分析，发现UFC1在多种肿瘤中异常高表达，提示其可能作为癌症诊断或治疗的潜在靶点。
4. **文献名称**: *"Structural insights into UFC1's catalytic mechanism using cryo-EM"*
**作者**: Wang, H. et al.
**摘要**: 结合抗体标记和冷冻电镜技术，解析UFC1的三维结构，阐明其催化泛素样蛋白修饰的分子机制。
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注：以上文献信息为示例性质，具体研究请通过学术数据库(如PubMed、Web of Science)检索真实文献。
The UFC1 antibody targets UFC1 (Ubiquitin-Fold Conjugating Enzyme 1), a protein involved in the ubiquitination pathway, a critical post-translational modification system that regulates protein degradation, signaling, and trafficking. UFC1. also known as UBE2A, functions as an E2 ubiquitin-conjugating enzyme, working with E3 ligases to transfer ubiquitin molecules to substrate proteins, marking them for proteasomal degradation or modulating their activity. It plays roles in DNA repair, cell cycle regulation, and stress responses.
Research on UFC1 has highlighted its association with neurodegenerative diseases, such as Alzheimer's, and cancer, where dysregulated ubiquitination contributes to pathological protein accumulation or oncogenic signaling. UFC1 antibodies are essential tools for studying these mechanisms, enabling detection of UFC1 expression levels, localization, and interactions in cellular and disease models.
Developed through hybridoma or recombinant technologies, UFC1 antibodies are validated for specificity in techniques like Western blot, immunohistochemistry, and co-immunoprecipitation. Their applications extend to biomarker discovery and therapeutic exploration, as targeting UFC1-mediated pathways could offer strategies to restore proteostasis in diseases linked to ubiquitin system dysfunction. Ongoing studies aim to clarify its precise regulatory roles and therapeutic potential.
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