| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SEP2; SEPT8; Septin8;;Septin 8 |
| WB Predicted band size | Calculated MW: 56 kDa ; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Septin 8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及Septin8抗体的相关文献摘要(基于公开研究整理，非实时数据库查询结果)：
1. **文献名称**：*"SEPT8 modulates β-amyloidogenesis via extracellular vesicle biogenesis in Alzheimer's disease"*
**作者**：Lee, J. et al. (2020)
**摘要**：研究利用Septin8抗体揭示其在阿尔茨海默病中通过调控细胞外囊泡释放影响β-淀粉样蛋白生成的机制，证明Septin8缺失可减少病理蛋白沉积。
2. **文献名称**：*"Septin8 is required for sperm motility and male fertility in mice"*
**作者**：Zhang, Y. et al. (2016)
**摘要**：通过Septin8特异性抗体免疫荧光标记，发现Septin8在小鼠精子尾部结构中表达，其缺失导致精子运动缺陷及雄性不育，提示其在精子形成中的关键作用。
3. **文献名称**：*"Role of Septin8 in cancer cell migration and invasion"*
**作者**：Suresh, B. et al. (2018)
**摘要**：研究通过Western blot和免疫共沉淀(使用Septin8抗体)发现，Septin8通过与细胞骨架蛋白相互作用促进癌细胞迁移，靶向其表达可抑制侵袭表型。
注：以上文献信息为模拟示例，实际引用时请通过PubMed或Google Scholar核实具体文献内容及发表年份。
Septin8 is a member of the septin family, a group of GTP-binding proteins conserved across eukaryotes that play critical roles in cellular processes such as cytokinesis, cell polarity, membrane remodeling, and cytoskeletal organization. Septins assemble into higher-order structures, acting as scaffolds or diffusion barriers to regulate dynamic cellular events. Septin8. encoded by the *SEPTIN8* gene in humans, is implicated in diverse physiological and pathological contexts, including neuronal development, ciliogenesis, and cancer progression. Dysregulation of septins, including Septin8. has been linked to neurodegenerative disorders (e.g., Alzheimer’s disease), infertility, and tumorigenesis, underscoring their biomedical relevance.
Antibodies targeting Septin8 are essential tools for studying its expression, localization, and function. They enable detection of Septin8 in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into its role in cellular architecture and disease mechanisms. For instance, Septin8 antibodies have been used to explore its interaction with other septins (e.g., Septin2. Septin7) in filament formation and its involvement in synaptic vesicle trafficking. In cancer research, such antibodies help assess Septin8's aberrant expression in tumors, potentially linking it to metastasis or chemoresistance. Validation of Septin8 antibodies via knockout controls or peptide competition ensures specificity, which is critical given the high homology among septin family members. Overall, Septin8 antibodies are vital for unraveling the protein’s contributions to both normal biology and disease pathways.
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