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Rabbit Monoclonal AZI2 Antibody

  • 中文名： AZI2抗体
  • 别    名： AZ2; AZI2; Nak associated protein 1; NAP1; TILP;;AZI2
货号: IPDX17902
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAZ2; AZI2; Nak associated protein 1; NAP1; TILP;;AZI2
WB Predicted band size45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human AZI2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与AZI2抗体相关的模拟参考文献(内容为虚构示例，仅作格式参考)：

1. **文献名称**：AZI2 modulates TLR3 signaling in dendritic cells via TRAF6 interaction

**作者**：Lee S, et al.

**摘要**：本研究利用AZI2特异性抗体进行免疫共沉淀实验，发现AZI2通过结合TRAF6蛋白调控Toll样受体3(TLR3)信号通路，影响树突状细胞的抗病毒反应。Western blot分析显示AZI2敲除导致下游NF-κB活性显著降低。

2. **文献名称**：AZI2 as a scaffold protein in hepatitis C virus replication

**作者**：Wang Y, et al.

**摘要**：通过免疫荧光染色(使用AZI2单克隆抗体)和蛋白质组学分析，揭示AZI2与HCV非结构蛋白NS5A相互作用，促进病毒复制复合体的组装。研究证实AZI2抗体可抑制病毒颗粒形成。

3. **文献名称**：Tissue-specific expression of AZI2 in autoimmune disorders

**作者**：Garcia-Ruiz C, et al.

**摘要**：通过免疫组织化学(IHC)结合AZI2多克隆抗体，发现AZI2在类风湿性关节炎患者的滑膜组织中高表达，并与炎症因子IL-6水平正相关，提示其作为潜在治疗靶点。

4. **文献名称**：AZI2 regulates T cell activation through membrane localization

**作者**：Tanaka K, et al.

**摘要**：使用AZI2抗体进行流式细胞术和亚细胞分选，证明AZI2通过锚定细胞膜上的脂筏结构调控T细胞受体(TCR)信号传导，影响CD4+ T细胞活化和增殖。

(注：以上文献及内容为示例，实际研究中请查阅真实数据库如PubMed。)

背景信息

The AZI2 (5-azacytidine-induced protein 2), also known as ZKSCAN3. is a zinc finger protein implicated in transcriptional regulation and cellular autophagy processes. It belongs to the SCAN domain-containing family of proteins, which are involved in chromatin remodeling and gene expression modulation. AZI2 functions as a transcription factor that binds to specific DNA sequences, regulating the expression of lysosomal and autophagy-related genes. Research has highlighted its role in maintaining cellular homeostasis, particularly under stress conditions, by balancing autophagic activity and nutrient metabolism. Dysregulation of AZI2 has been associated with cancer progression, immune responses, and neurodegenerative diseases. For instance, it is overexpressed in certain cancers, where it may promote tumor survival by enhancing lysosomal function and drug resistance. The AZI2 antibody is a critical tool for studying these mechanisms, enabling the detection and localization of AZI2 in cells and tissues via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its application extends to elucidating AZI2’s interaction networks, post-translational modifications, and downstream targets. Recent studies also explore AZI2’s potential as a therapeutic target, particularly in cancers with aberrant autophagy signaling. This antibody thus serves as a vital reagent for dissecting AZI2’s biological roles and its implications in disease pathogenesis.

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