| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SAP-3; GM2-AP |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GM2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SNX5抗体的3篇文献示例(内容为模拟生成，仅供参考)：
---
1. **文献名称**: *Sorting Nexin 5 regulates retrograde transport and actin cytoskeleton dynamics*
**作者**: Wang, X. et al.
**摘要**: 本研究利用SNX5特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了SNX5在调控逆行运输(如Retromer复合体介导的膜蛋白回收)中的作用，并发现其通过结合细胞骨架蛋白影响肌动蛋白动态，为神经退行性疾病机制提供了新见解。
---
2. **文献名称**: *SNX5 modulates EGFR trafficking and signaling in cancer cells*
**作者**: Chen, L. et al.
**摘要**: 通过Western blot和免疫组化实验结合SNX5抗体，研究发现SNX5通过介导EGFR的内体分选影响其降解与再循环，SNX5敲低导致EGFR信号通路异常激活，促进肿瘤细胞增殖，提示其在癌症靶向治疗中的潜在价值。
---
3. **文献名称**: *SNX5 antibody-based profiling reveals its role in autophagosome-lysosome fusion*
**作者**: Müller, R. et al.
**摘要**: 利用SNX5抗体的免疫电镜和活细胞成像技术，证明SNX5通过调控内体-溶酶体膜接触点参与自噬体成熟过程，其缺失导致自噬通量障碍，可能与代谢性疾病相关。
---
**备注**：以上文献为示例，实际研究中建议通过PubMed、Google Scholar等平台检索真实发表的论文(关键词：SNX5 antibody, Sorting Nexin 5 function)。若需具体文献，可提供更详细的研究方向(如疾病模型、相互作用蛋白等)。
SNX5 (Sorting Nexin 5) is a member of the sorting nexin family of proteins, which are involved in intracellular trafficking, membrane remodeling, and signal transduction. These proteins typically contain a phox homology (PX) domain that binds phosphoinositides, enabling their association with specific cellular membranes. SNX5. in particular, interacts with other sorting nexins (e.g., SNX6 or SNX1) to form heterodimeric complexes, such as the retromer-associated subcomplex, which plays a critical role in endosomal sorting and retrograde transport of cargo proteins from endosomes to the trans-Golgi network. SNX5 also participates in regulating lysosome biogenesis, cell migration, and autophagy. Its BAR (Bin/Amphiphysin/Rvs) domain facilitates membrane curvature sensing and tubulation, contributing to vesicle formation.
Antibodies targeting SNX5 are essential tools for studying its expression, localization, and function. These antibodies are typically raised in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments unique to SNX5. They are validated for applications such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry. Researchers use SNX5 antibodies to investigate its role in diseases linked to trafficking defects, including neurodegenerative disorders, cancer, and metabolic syndromes. Specificity is confirmed through knockdown/knockout controls or comparative analysis with related sorting nexins. Commercial SNX5 antibodies are available as monoclonal or polyclonal preparations, often with epitope and cross-reactivity data provided to ensure reproducibility in experimental models.
×
