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Rabbit Monoclonal PPM1G Antibody

  • 中文名： PPM1G抗体
  • 别    名： PP2C; PP2C gamma; PP2CG; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G;;PPM1G
货号: IPDX17896
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPP2C; PP2C gamma; PP2CG; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G;;PPM1G
WB Predicted band sizeCalculated MW: 59 kDa ; Observed MW: 75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthesized peptide derived from human PPM1G
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于PPM1G抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：

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1. **文献名称**：*"PPM1G regulates the DNA damage response by dephosphorylating H2AX"*

**作者**：Lu et al.

**摘要**：本研究利用PPM1G抗体通过Western blot和免疫荧光技术，揭示了PPM1G通过去磷酸化γ-H2AX参与DNA损伤修复的机制，表明其在维持基因组稳定性中的关键作用。

2. **文献名称**：*"The role of PPM1G in spliceosome assembly and pre-mRNA splicing"*

**作者**：Smith et al.

**摘要**：通过免疫共沉淀(Co-IP)和质谱分析，研究者使用PPM1G抗体鉴定了其与剪接体蛋白的相互作用，证明PPM1G通过调控剪接体动态影响RNA加工过程。

3. **文献名称**：*"PPM1G overexpression correlates with poor prognosis in hepatocellular carcinoma"*

**作者**：Zhang et al.

**摘要**：该研究采用PPM1G抗体进行免疫组化(IHC)分析，发现PPM1G在肝癌组织中高表达，且与患者生存率显著相关，提示其作为潜在预后标志物的可能性。

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**备注**：上述文献为示例，实际引用时建议通过PubMed或Google Scholar以关键词“PPM1G antibody”、“PPM1G function”等检索最新研究，并核实实验方法中抗体的具体应用(如货号、公司等)。

背景信息

The PPM1G antibody is a tool used to detect and study the protein phosphatase, Mg²⁺/Mn²⁺-dependent 1G (PPM1G), also known as PP2Cγ. PPM1G belongs to the PPM family of serine/threonine phosphatases, which regulate diverse cellular processes by dephosphorylating key signaling molecules. This enzyme plays critical roles in DNA damage response, RNA splicing, cell cycle progression, and stress signaling. For instance, PPM1G dephosphorylates components of the spliceosome complex to modulate pre-mRNA processing and interacts with ATM/ATR kinases to influence DNA repair pathways. Dysregulation of PPM1G has been linked to cancers, neurological disorders, and metabolic diseases, making it a target for mechanistic and therapeutic research. The PPM1G antibody is widely employed in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to assess protein expression, localization, and interactions. Its specificity varies depending on the epitope and validation methods, requiring careful selection for experimental accuracy. Studies using this antibody have contributed to understanding PPM1G’s role in dephosphorylating substrates such as MDM2. RPA2. and S6K1. highlighting its regulatory impact on p53-mediated apoptosis, replication stress, and mTOR signaling. Ongoing research aims to clarify its tissue-specific functions and potential as a biomarker or drug target.

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