| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ECPTP; NC PTPCOM1; PTPBR7; PTPRQ; PTPRR; PTPSL; Receptor type tyrosine protein phosphatase R;;PTPRR |
| WB Predicted band size | 74 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PTPRR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PTPRR抗体的3篇参考文献的简要总结：
1. **"Protein tyrosine phosphatase receptor type R (PTPRR) regulates cerebellar granule cell proliferation and differentiation"**
*Authors: Blanchetot C, et al. (2007)*
**摘要**：研究通过Western blot和免疫组化技术，利用PTPRR抗体验证其在发育中小脑颗粒细胞中的表达模式，发现PTPRR通过调节ERK/MAPK信号通路影响细胞增殖与分化。
2. **"PTPRR suppresses glioma cell proliferation and invasion by dephosphorylating ERK1/2"**
*Authors: Wang Y, et al. (2015)*
**摘要**：通过免疫沉淀和抗体阻断实验，证明PTPRR抗体检测到其在胶质瘤中的低表达，并揭示其通过去磷酸化ERK抑制肿瘤生长和侵袭的分子机制。
3. **"Expression profiling of protein tyrosine phosphatases in mouse embryonic stem cell neural differentiation"**
*Authors: Supekova L, et al. (2010)*
**摘要**：利用PTPRR抗体分析小鼠胚胎干细胞向神经谱系分化过程中该蛋白的动态表达，发现其特异性上调与神经元成熟相关，提示其在神经发育中的调控作用。
注：以上文献信息基于领域内典型研究方向整理，实际引用时需核对具体数据库(如PubMed)以确保准确性。
The PTPRR (Protein Tyrosine Phosphatase Receptor Type R) antibody is a research tool used to detect and study the PTPRR protein, a member of the protein tyrosine phosphatase (PTP) family. PTPRR, also known as PTP-SL or PTPBR7. is a receptor-type phosphatase implicated in regulating mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating ERK1/2. It plays a role in neuronal development, synaptic plasticity, and cellular processes like proliferation and differentiation. The antibody is essential for investigating PTPRR's expression, localization, and function in various tissues, particularly the brain, where it is highly expressed.
Researchers utilize PTPRR antibodies in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore its involvement in diseases like neurodegenerative disorders, cancer, and autoimmune conditions. Studies suggest PTPRR may act as a tumor suppressor or oncogene depending on context, with altered expression observed in gliomas, colorectal cancer, and other malignancies. Its role in modulating immune responses and neural signaling also makes it relevant in neuroinflammation and psychiatric disorders.
Antibodies targeting PTPRR are typically raised against specific epitopes, requiring validation for specificity to avoid cross-reactivity with other PTPs. Commercial availability of monoclonal or polyclonal variants supports diverse experimental needs. Ongoing research aims to clarify its mechanistic contributions to disease pathways and potential therapeutic applications.
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