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Rabbit Monoclonal TMEM192 Antibody

  • 中文名： TMEM192抗体
  • 别    名： TMEM192; Transmembrane protein 192;;TMEM192
货号: IPDX17894
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTMEM192; Transmembrane protein 192;;TMEM192
WB Predicted band sizeCalculated MW: 31 kDa ; Observed MW: 29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TMEM192
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TMEM192抗体的3篇参考文献及其摘要概括(文献为虚拟示例，仅供参考)：

1. **《TMEM192作为溶酶体标志物在亚细胞蛋白质组学中的应用》**

- 作者：Abu-Remaileh, M., et al.

- 摘要：本研究验证了TMEM192抗体在溶酶体分离和标记中的特异性，通过免疫印迹和免疫荧光证实其定位于溶酶体膜，为溶酶体相关疾病的蛋白质组学研究提供了可靠工具。

2. **《通过TMEM192抗体揭示溶酶体在神经退行性疾病中的动态变化》**

- 作者：Jourdan, T., et al.

- 摘要：利用TMEM192抗体追踪阿尔茨海默病模型中溶酶体的数量及定位变化，发现疾病进展中溶酶体膜稳定性降低，提示其与神经元损伤的相关性。

3. **《基于TMEM2抗体的新型溶酶体分离方法开发》**

- 作者：Chen, Y., et al.

- 摘要：开发了一种基于TMEM192抗体免疫亲和层析的溶酶体纯化技术，显著提高了溶酶体分离效率，并应用于癌症细胞代谢重编程研究。

(注：以上文献为示例，实际文献需通过PubMed或Google Scholar检索确认。)

背景信息

The TMEM192 (Transmembrane Protein 192) antibody is a tool used to study the TMEM192 protein, a poorly characterized transmembrane protein implicated in lysosomal and endosomal pathways. TMEM192 is thought to play roles in organelle membrane dynamics, cellular trafficking, or ion transport, though its precise biological function remains under investigation. Research suggests its potential involvement in autophagy and lysosomal degradation processes, with possible links to neurodegenerative diseases and cancer. The TMEM192 antibody, typically developed as a monoclonal or polyclonal reagent, enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its utility extends to exploring TMEM192 expression patterns across tissues, subcellular distribution, and interactions with other proteins. Recent studies have utilized this antibody to investigate TMEM192's role in lysosomal pH regulation and its association with diseases like Alzheimer's, where lysosomal dysfunction is a hallmark. Validation of TMEM192 antibody specificity often involves knockout cell lines or siRNA-mediated protein depletion. Commercial availability of this antibody supports ongoing research to clarify TMEM192's molecular mechanisms and therapeutic potential.

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