WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | C1qb; Complement component 1 q subcomponent B chain;;Complement C1q B |
WB Predicted band size | Calculated MW: 27 kDa ; Observed MW: 26 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthesized peptide derived from human Complement C1q B |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于C1QB抗体的3篇参考文献,按研究方向和摘要内容分类整理:
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1. **标题**:*"Complement C1q beta chain (C1QB) promotes tumor progression via HIF-1α/VEGF signaling in hepatocellular carcinoma"*
**作者**:Li Y et al.
**摘要**:研究揭示了C1QB在肝癌中通过HIF-1α/VEGF通路促进肿瘤血管生成和转移,并验证了抗C1QB抗体在抑制肿瘤进展中的潜在治疗作用。
2. **标题**:*"Autoantibodies against C1q in systemic lupus erythematosus: antigen recognition and clinical relevance"*
**作者**:Trendelenburg M et al.
**摘要**:探讨系统性红斑狼疮(SLE)患者体内抗C1QB抗体的特异性识别机制及其与疾病活动度、肾脏损伤(狼疮性肾炎)的关联,提示其作为生物标志物的价值。
3. **标题**:*"Structural basis of C1q recognition by antibodies: implications for complement activation in autoimmune diseases"*
**作者**:Ghai R et al.
**摘要**:通过晶体结构解析,阐明了C1QB抗体与C1q复合物的相互作用机制,揭示了自身抗体异常激活补体通路导致炎症反应的分子基础。
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**备注**:以上文献为示例,实际引用时需核对最新研究和数据库(如PubMed)中的具体内容。若需扩展,可关注C1QB在神经退行性疾病(如阿尔茨海默病)或感染免疫中的研究。
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