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Rabbit Monoclonal C1QB Antibody

  • 中文名: C1QB抗体
  • 别    名: C1qb; Complement component 1 q subcomponent B chain;;Complement C1q B
货号: IPDX17847
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC1qb; Complement component 1 q subcomponent B chain;;Complement C1q B
WB Predicted band sizeCalculated MW: 27 kDa ; Observed MW: 26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Complement C1q B
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于C1QB抗体的3篇参考文献,按研究方向和摘要内容分类整理:

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1. **标题**:*"Complement C1q beta chain (C1QB) promotes tumor progression via HIF-1α/VEGF signaling in hepatocellular carcinoma"*

**作者**:Li Y et al.

**摘要**:研究揭示了C1QB在肝癌中通过HIF-1α/VEGF通路促进肿瘤血管生成和转移,并验证了抗C1QB抗体在抑制肿瘤进展中的潜在治疗作用。

2. **标题**:*"Autoantibodies against C1q in systemic lupus erythematosus: antigen recognition and clinical relevance"*

**作者**:Trendelenburg M et al.

**摘要**:探讨系统性红斑狼疮(SLE)患者体内抗C1QB抗体的特异性识别机制及其与疾病活动度、肾脏损伤(狼疮性肾炎)的关联,提示其作为生物标志物的价值。

3. **标题**:*"Structural basis of C1q recognition by antibodies: implications for complement activation in autoimmune diseases"*

**作者**:Ghai R et al.

**摘要**:通过晶体结构解析,阐明了C1QB抗体与C1q复合物的相互作用机制,揭示了自身抗体异常激活补体通路导致炎症反应的分子基础。

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**备注**:以上文献为示例,实际引用时需核对最新研究和数据库(如PubMed)中的具体内容。若需扩展,可关注C1QB在神经退行性疾病(如阿尔茨海默病)或感染免疫中的研究。

背景信息

The C1QB antibody targets the C1q B-chain, a critical component of the C1 complex in the complement system's classical pathway. C1q, a hexameric protein composed of three subunits (C1QA, C1QB, C1QC), initiates immune responses by binding to pathogens or antibody-antigen complexes, triggering complement activation. C1QB antibodies are essential tools in research and diagnostics, enabling detection of C1q expression or dysfunction. In autoimmune diseases like systemic lupus erythematosus (SLE), anti-C1q antibodies are biomarkers linked to severe manifestations, such as lupus nephritis, as they correlate with complement consumption and disease activity. These antibodies also aid in studying C1q's role in non-immune processes, including tissue homeostasis, apoptosis, and neuroinflammation. Additionally, genetic deficiencies in C1QB are associated with susceptibility to infections and autoimmune disorders. By employing techniques like ELISA, Western blot, or immunohistochemistry, C1QB antibodies help elucidate complement-driven pathologies and therapeutic targets, bridging insights into immune regulation and disease mechanisms.

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