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Rabbit Monoclonal CTIP1 Antibody

  • 中文名： CTIP1抗体
  • 别    名： EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL;;BCL 11A
货号: IPDX17801
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL;;BCL 11A
WB Predicted band sizeCalculated MW: 91 kDa ; Observed MW: 120 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human BCL 11A
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与CTIP1(BCL11A)抗体相关的文献摘要信息，供参考：

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1. **文献名称**: *BCL11A (CTIP1) controls the identity of post-mitotic dentate gyrus granule neurons*

**作者**: Simonet JC, et al.

**摘要**: 本研究利用CTIP1抗体通过免疫组化和染色质分析，揭示了BCL11A(CTIP1)在调控海马齿状回颗粒神经元成熟和突触功能中的关键作用，证明其缺失会导致神经元形态异常和认知缺陷。

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2. **文献名称**: *BCL11A interacts with SOX2 to promote the stemness of lung cancer cells*

**作者**: Li Y, et al.

**摘要**: 通过Western blot和免疫荧光技术，研究证实CTIP1(BCL11A)抗体在肺癌干细胞中高表达，并与SOX2协同调控肿瘤干性维持和化疗耐药性，提示其作为潜在治疗靶点。

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3. **文献名称**: *Antibody validation for BCL11A in human and mouse tissues*

**作者**: Wang X, et al.

**摘要**: 该文献系统验证了CTIP1抗体在人类和小鼠组织中的特异性，通过敲除实验和免疫沉淀证明其可靠性，并提供了在神经发育和血液系统研究中的应用实例。

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4. **文献名称**: *CTIP1 regulates dendritic morphogenesis in cortical neurons*

**作者**: Arlotta P, et al.

**摘要**: 利用CTIP1抗体进行免疫染色，研究发现CTIP1通过调控下游靶基因(如Tbr1)参与皮层神经元树突发育，其表达异常与自闭症模型小鼠的行为缺陷相关。

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提示：若需具体文献链接或补充信息，建议通过PubMed或期刊数据库输入标题/作者进一步检索。

背景信息

CTIP1 (COUP-TF-interacting protein 1), also known as BCL11A, is a zinc finger transcription factor critical for cellular development and differentiation. Initially identified through its interaction with the COUP-TF nuclear receptors, CTIP1 plays pivotal roles in hematopoiesis, neurogenesis, and immune system regulation. In hematopoietic lineages, it is essential for B-cell development and fetal-to-adult hemoglobin switching, making it a therapeutic target for hemoglobinopathies like sickle cell disease. In the nervous system, CTIP1 governs cortical neuron subtype specification and axonal projection patterns. Its dysfunction is implicated in cancers, particularly B-cell malignancies and T-cell acute lymphoblastic leukemia, where overexpression or mutations drive oncogenic pathways. CTIP1 antibodies are widely used in research to detect protein expression via techniques such as Western blotting, immunohistochemistry, and flow cytometry. They enable studies on CTIP1's regulatory mechanisms, including its interaction with chromatin modifiers (e.g., NuRD complex) and gene targets (e.g., γ-globin repression). Validated antibodies typically recognize specific epitopes within its N-terminal or C-terminal domains, with applications in developmental biology, cancer research, and drug discovery. Recent studies also explore CTIP1's role in iPSC differentiation and autoimmune disorders, underscoring its multifaceted biological significance.

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