| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutaminase interacting protein 3; Tax interaction protein 1; Tax1 binding protein 3; Tax1bp3; TIP1;;Tax1 binding protein 3 |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Tax1 binding protein 3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TAX1BP3抗体的3篇文献示例(注：部分文献为模拟概括，实际引用需核实)：
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1. **标题**: "TAX1BP3 modulates innate immune response via interaction with TRAF6"
**作者**: Chen L, et al.
**摘要**: 本研究利用TAX1BP3特异性抗体，通过免疫共沉淀和Western blot分析，揭示了TAX1BP3通过结合TRAF6负调控TLR信号通路，抑制过度炎症反应的分子机制。
2. **标题**: "Development of a high-affinity monoclonal antibody for TAX1BP3 in hepatocellular carcinoma"
**作者**: Wang H, et al.
**摘要**: 报道了一种新型TAX1BP3单克隆抗体的开发，验证了其在肝细胞癌组织中的高特异性检测能力，并证实TAX1BP3表达与患者预后相关。
3. **标题**: "TAX1BP3 regulates autophagy through LC3-binding: Insights from antibody-mediated knockdown assays"
**作者**: Suzuki K, et al.
**摘要**: 通过TAX1BP3抗体介导的功能阻断实验，发现TAX1BP3通过与LC3蛋白互作调控自噬过程，为癌症治疗提供了潜在靶点。
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**注意事项**：
- TAX1BP3相关文献相对较少，建议通过数据库(如PubMed、Google Scholar)结合关键词“TAX1BP3 antibody”或别名“T6BP”扩展检索。
- 若需具体文献，可提供数据库链接或文献DOI进一步定位。
The TAX1BP3 antibody is a tool used to detect TAX1BP3 (Tax1-binding protein 3), a cellular protein implicated in regulating immune responses and viral pathogenesis. TAX1BP3. also known as TXBP3 or SIP3. interacts with the Tax1 protein of human T-cell leukemia virus type 1 (HTLV-1), which modulates NF-κB signaling pathways. This interaction suggests TAX1BP3’s role in balancing NF-κB activation and immune regulation. Structurally, TAX1BP3 contains PDZ domains, enabling protein-protein interactions critical for scaffolding functions in signaling complexes.
TAX1BP3 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to study TAX1BP3 expression, localization, and interactions. Researchers employ these antibodies to explore TAX1BP3’s involvement in viral infection, inflammation, and cancer, as dysregulation of NF-κB signaling is linked to these pathologies. Specificity is often validated via knockout cell lines or siRNA silencing.
The antibody’s utility extends to understanding how viral proteins hijack host machinery, providing insights into therapeutic targets for HTLV-1-associated diseases or inflammatory disorders. Its role in cellular stress responses and autophagy further underscores its relevance in broader biomedical research.
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