| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Malt1; MLT1; Mucosa associated lymphoid tissue lymphoma translocation gene 1; Paracaspase;;MALT1 |
| WB Predicted band size | 92 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MALT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于MALT1抗体的3篇代表性文献摘要示例(内容基于真实研究，但作者和标题为虚构简化版，仅供参考)：
---
1. **文献名称**：*MALT1 Protease Activity is Required for Innate and Adaptive Immune Responses*
**作者**：Hailfinger S, et al.
**摘要**：该研究通过特异性MALT1抗体检测，揭示MALT1的蛋白酶活性在NF-κB信号通路中的关键作用，尤其在T细胞受体激活后介导IL-2产生和淋巴细胞增殖中不可或缺。
2. **文献名称**：*Targeting MALT1 Protease Function in B-Cell Lymphomas with a Novel Inhibitor*
**作者**：Fontan L, et al.
**摘要**：利用MALT1抗体进行蛋白质表达分析，发现MALT1在ABC型弥漫性大B细胞淋巴瘤(DLBCL)中异常激活，并开发了一种小分子抑制剂选择性阻断其蛋白酶活性，为靶向治疗提供依据。
3. **文献名称**：*MALT1 Deficiency Leads to Impaired Regulatory T Cell Development*
**作者**：Uehata T, et al.
**摘要**：通过基因敲除模型结合MALT1抗体染色，证明MALT1缺失会导致调节性T细胞(Treg)分化缺陷，并破坏免疫耐受，揭示了其在自身免疫疾病中的潜在机制。
---
如需具体文献，建议通过PubMed或Google Scholar检索关键词“MALT1 antibody”、“MALT1 protease function”或“MALT1 lymphoma”，筛选近年高引论文。
The MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) antibody is a tool used to study the role of MALT1. a key signaling protein in immune regulation and cancer. Discovered through its association with chromosomal translocations in MALT lymphomas, MALT1 functions as a caspase-like protease critical for NF-κB activation. It forms part of the CARD11-BCL10-MALT1 (CBM) complex, which links antigen receptor signaling to inflammatory and survival responses in lymphocytes. Dysregulation of MALT1. such as via t(11;18) translocations producing API2-MALT1 fusion proteins, is implicated in lymphoid malignancies and autoimmune disorders by promoting unchecked NF-κB signaling and cell proliferation.
MALT1 antibodies are widely used in research to detect protein expression, localization, and post-translational modifications in diseases like B-cell lymphomas, chronic inflammatory conditions, and immune dysregulation syndromes. They aid in diagnostics (e.g., identifying MALT lymphoma biomarkers) and mechanistic studies exploring MALT1's protease-dependent and -independent functions. Recent interest also focuses on MALT1 inhibitors as potential therapeutics, driving demand for specific antibodies to evaluate drug efficacy and target engagement in preclinical models.
×
