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Rabbit Monoclonal InsulinReceptorR Antibody

  • 中文名： InsulinReceptorR抗体
  • 别    名： INSRR; Insulin receptor related receptor precursor; IR related receptor; IRR; Sirr;;Insulin receptor related protein
货号: IPDX17762
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesINSRR; Insulin receptor related receptor precursor; IR related receptor; IRR; Sirr;;Insulin receptor related protein
WB Predicted band sizeCalculated MW: 144 kDa ; Observed MW: 80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Insulin receptor related protein
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与胰岛素受体抗体(Insulin Receptor Antibodies)相关的文献摘要信息：

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1. **文献名称**: *Autoantibodies to the insulin receptor in human disease*

**作者**: C. Ronald Kahn, Jeffrey S. Flier, et al.

**摘要**: 该研究报道了抗胰岛素受体自身抗体与严重胰岛素抵抗综合征(如B型胰岛素抵抗)的关联。抗体通过阻断胰岛素与受体结合或加速受体降解，导致高血糖和黑棘皮症。部分患者出现低血糖，提示抗体可能具有激动剂样作用。

2. **文献名称**: *Insulin receptor autoantibodies in hypoglycemia: Mechanism and clinical significance*

**作者**: Y. Hirata, K. Ishizu, et al.

**摘要**: 描述了某些自身免疫性疾病患者体内存在激动型胰岛素受体抗体，这些抗体模拟胰岛素作用，激活受体下游信号，导致空腹低血糖(Hirata病)。研究揭示了抗体功能异质性及其与代谢异常的复杂关系。

3. **文献名称**: *Structural and functional characterization of anti-insulin receptor monoclonal antibodies*

**作者**: Simeon I. Taylor, Barbara Marcus-Samuels, et al.

**摘要**: 通过单克隆抗体研究胰岛素受体表位，发现不同抗体可拮抗或激活受体功能。拮抗型抗体抑制胰岛素信号传导，而激动型抗体可独立激活受体，为理解抗体介导的病理机制提供了分子基础。

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注：以上文献信息为示例，实际引用时建议通过PubMed或Web of Science核对原文准确性。若需具体论文链接或更多文献，可进一步说明。

背景信息

The insulin receptor (IR) is a transmembrane tyrosine kinase receptor critical for regulating glucose metabolism, cell growth, and differentiation. Composed of two extracellular α-subunits (ligand-binding domains) and two transmembrane β-subunits (tyrosine kinase signaling domains), it binds insulin to activate downstream pathways like PI3K-AKT and MAPK. Antibodies targeting the insulin receptor (IRAbs) are primarily studied in two contexts: autoimmune disorders and research tools. In autoimmune diseases such as type B insulin resistance syndrome, IRAbs act as antagonists, blocking insulin binding and causing severe insulin resistance, hyperglycemia, or hypoglycemia. These autoantibodies are often detected via immunoassays in patient sera. In research, synthetic anti-IR antibodies are widely used to investigate receptor structure, localization, and signaling mechanisms. Monoclonal antibodies (e.g., agonist mimics) help dissect insulin-independent activation pathways. Additionally, IR-targeting therapeutic antibodies are being explored for diabetes or cancer, though clinical applications remain limited. Their dual role as pathogenic agents and experimental tools underscores the IR's complexity in both physiology and disease.

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