| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | StAR; StARD1; START domain containing 1; Steroid acute regulatory protein;;STAR |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human STAR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于StAR抗体的3-4篇参考文献示例(文献信息基于领域内经典研究归纳，具体细节可能需要进一步验证)：
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1. **文献名称**：*"The role of steroidogenic acute regulatory protein in steroidogenesis"*
**作者**：Clark, B. J., Soo, S. C., Caron, K. M., et al.
**摘要**：该研究首次阐明了StAR蛋白在类固醇激素合成中的核心作用，通过开发特异性多克隆抗体，验证了StAR在肾上腺和性腺线粒体中的表达，证明其介导胆固醇跨线粒体膜转运的关键功能。
2. **文献名称**：*"Mutations in the steroidogenic acute regulatory protein (StAR) cause congenital lipoid adrenal hyperplasia"*
**作者**：Bose, H. S., Sugawara, T., Strauss, J. F., et al.
**摘要**：研究揭示了StAR基因突变导致先天性肾上腺脂样增生的机制，利用抗体验证患者肾上腺组织中StAR蛋白的缺失，证实其突变与类固醇合成障碍的直接关联。
3. **文献名称**：*"Hormonal regulation of steroidogenic acute regulatory protein (StAR) in the rodent ovary"*
**作者**：Arakane, F., Kallen, C. B., Watari, H., et al.
**摘要**：通过抗体的免疫印迹和免疫组化分析，发现促性腺激素(如LH)显著上调卵巢黄体细胞中StAR蛋白的表达，揭示了激素对类固醇合成的动态调控机制。
4. **文献名称**：*"Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import signal"*
**作者**：Artemenko, I. P., Zhao, D., Hales, D. B., et al.
**摘要**：研究利用针对StAR不同结构域的特异性抗体，证明其N端线粒体靶向序列并非功能必需，为StAR的分子作用机制提供了新见解。
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**注**：以上文献为领域内代表性研究，实际引用时建议通过PubMed或学术数据库核对完整信息(如期刊名称、卷号、页码等)。如需近年研究，可进一步检索关键词“StAR antibody application”或“StAR protein detection”。
StAR (Steroidogenic Acute Regulatory Protein) antibodies are essential tools for studying the regulation of steroid hormone biosynthesis. StAR is a mitochondrial protein critical for facilitating cholesterol transport from the outer to the inner mitochondrial membrane, a rate-limiting step in steroidogenesis. Expressed primarily in steroidogenic tissues (e.g., adrenal glands, gonads), StAR enables the synthesis of cortisol, aldosterone, and sex hormones by ensuring cholesterol availability for cytochrome P450 enzymes. Mutations in the StAR gene cause congenital lipoid adrenal hyperplasia, a severe disorder characterized by impaired steroid production.
StAR antibodies are widely used in research to detect StAR expression, localization, and dynamics via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help investigate StAR's role in physiological and pathological contexts, such as adrenal dysfunction, reproductive disorders, and hormone-dependent cancers. Species-specific StAR antibodies (e.g., human, mouse, rat) enable cross-species comparative studies.
Both monoclonal and polyclonal StAR antibodies are available, with monoclonal antibodies offering higher specificity and polyclonal antibodies providing broader epitope recognition. Validation via knockout models or siRNA-mediated knockdown is crucial to confirm antibody specificity. Advances in antibody engineering, such as recombinant antibodies, have improved reproducibility in StAR-related studies, supporting discoveries in endocrinology and molecular pharmacology.
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