| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein NDRG1; Differentiation-related gene 1 protein; DRG-1; RTP; Rit42; NDRG1; CAP43; DRG1; RTP; targ1; TDD5; tdds;;NDRG1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NDRG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于NDRG1抗体的3篇参考文献的简要概括：
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1. **文献名称**: *NDRG1 is a biomarker for progression and prognosis in colorectal cancer*
**作者**: Liu W, et al.
**摘要**: 该研究通过免疫组化(使用NDRG1抗体)分析结直肠癌组织中NDRG1的表达，发现其高表达与肿瘤转移和不良预后显著相关，提示NDRG1可作为结直肠癌的潜在预后标志物。
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2. **文献名称**: *The role of NDRG1 in the hypoxia-induced progression of glioblastoma*
**作者**: Chen Z, et al.
**摘要**: 研究利用NDRG1抗体进行Western blot和免疫荧光实验，证实低氧条件下NDRG1在胶质母细胞瘤中表达上调，并通过调控HIF-1α信号通路促进肿瘤侵袭和血管生成。
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3. **文献名称**: *NDRG1 suppresses prostate cancer invasion by regulating F-actin cytoskeleton organization*
**作者**: Zhang J, et al.
**摘要**: 通过NDRG1抗体检测前列腺癌细胞系中的蛋白表达，发现NDRG1通过抑制RhoA/ROCK通路调控细胞骨架重组，从而降低肿瘤细胞的迁移和侵袭能力。
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4. **文献名称**: *Antibody-based detection of NDRG1 in breast cancer: correlation with molecular subtypes*
**作者**: Wang Y, et al.
**摘要**: 研究使用NDRG1抗体对乳腺癌组织进行免疫组化分析，发现NDRG1在三阴性乳腺癌中表达显著升高，并与化疗耐药性相关，提示其作为治疗靶点的潜力。
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以上文献均聚焦于NDRG1在不同癌症中的功能及其抗体在实验中的应用，涵盖预后评估、分子机制和临床相关性研究。
The NDRG1 (N-myc downstream-regulated gene 1) antibody is a critical tool for studying the expression and function of the NDRG1 protein, a ubiquitously expressed stress-responsive gene product implicated in diverse cellular processes, including cell differentiation, proliferation, and stress responses. NDRG1 is regulated by various stimuli, such as hypoxia, DNA damage, and metal ions, and interacts with signaling pathways like the PI3K/AKT and hypoxia-inducible factor 1-alpha (HIF-1α) pathways. It has dual roles in cancer biology, acting as a metastasis suppressor in prostate, breast, and colon cancers, while paradoxically promoting tumor progression in other contexts. NDRG1 also plays roles in neurological disorders, myelin maintenance, and metabolic regulation.
NDRG1 antibodies are widely used in research to detect protein expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate NDRG1’s tissue-specific localization, post-translational modifications, and interactions with other proteins. Clinically, NDRG1 expression is explored as a biomarker for cancer prognosis, nerve injury, and hypoxia-related pathologies. However, challenges remain in standardizing antibody specificity due to NDRG1’s homology with other NDRG family members and variable isoforms. Ongoing studies aim to clarify its mechanistic roles and therapeutic potential across diseases.
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