| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a;;Prolactin receptor |
| WB Predicted band size | Calculated MW: 70 kDa ; Observed MW: 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Prolactin receptor |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于催乳素受体(Prolactin Receptor, PRLR)抗体的3-4篇文献摘要概括，按规范格式整理：
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1. **文献名称**：*Prolactin receptor antagonists*
**作者**：Bole-Feysot, C. et al.
**摘要**：该研究探讨了催乳素受体抗体的生成及其在检测PRLR表达中的应用，通过免疫沉淀和免疫印迹技术验证了抗体的特异性，并分析了PRLR在不同组织中的分布。
2. **文献名称**：*Prolactin receptor signaling mechanisms in mammary gland development*
**作者**：Horseman, N.D.
**摘要**：综述了催乳素受体信号通路在乳腺发育中的作用，包括使用特异性抗体研究受体磷酸化及下游STAT5信号激活的分子机制。
3. **文献名称**：*Prolactin receptor knockout mice exhibit reduced neural progenitor cell proliferation*
**作者**：Trott, J.F. et al.
**摘要**：利用PRLR基因敲除小鼠模型和抗体验证，发现催乳素受体缺失导致神经干细胞增殖减少，提示其在神经发育中的潜在功能。
4. **文献名称**：*Prolactin receptor expression in breast cancer: A potential therapeutic target*
**作者**：Bernardo, G.M. & Keri, R.A.
**摘要**：通过免疫组化分析PRLR抗体标记的受体表达水平，发现其在乳腺癌中的高表达与激素依赖性肿瘤进展相关，提出了靶向治疗的可行性。
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以上文献涵盖抗体的应用场景(如检测、信号机制研究、疾病模型及治疗)，具体发表年份可参考PubMed或期刊官网获取完整信息。
The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily. It mediates the physiological effects of prolactin (PRL), a hormone primarily associated with lactation, reproduction, metabolism, and immune regulation. Structurally, PRLR consists of an extracellular ligand-binding domain, a transmembrane region, and an intracellular signaling domain. Upon PRL binding, PRLR dimerizes and activates downstream signaling pathways, including JAK2-STAT5. MAPK, and PI3K-Akt, regulating gene expression and cellular responses.
PRLR antibodies are essential tools for studying receptor expression, localization, and function in various tissues (e.g., mammary glands, liver, prostate) and disease contexts. They enable detection of PRLR isoforms (short/long forms) and post-translational modifications via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). In research, these antibodies help elucidate PRLR's role in pathologies such as breast cancer, prostate hyperplasia, and reproductive disorders. For instance, elevated PRLR expression in tumors correlates with proliferation and metastasis, making it a potential therapeutic target.
Commercially available PRLR antibodies vary in species reactivity (human, mouse, rat) and clonality (monoclonal/polyoclonal). Validation for specificity (e.g., knockout controls) and application compatibility is critical to ensure reliability. Recent studies also utilize PRLR antibodies to explore PRL-independent signaling mechanisms and crosstalk with other hormone pathways, expanding understanding of its multifunctional roles.
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