| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GABA-B receptor 1; GABA-B-R1; GABAB R1; GABAB subunit 1c; GABABR1; GABBR1 3; Gamma aminobutyric acid (GABA) B receptor 1; Gb1; GPRC3A;;GABA B receptor 1 |
| WB Predicted band size | 108 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GABA B receptor 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GABAB Receptor 1抗体的3篇代表性文献，按研究内容和应用方向整理：
1. **文献名称**：Immunohistochemical localization of GABA_B receptor 1 in the rat brain
**作者**：Bischoff S. et al.
**摘要**：该研究利用特异性GABABR1抗体，通过免疫组化技术系统定位了GABAB受体1亚型在大鼠脑区的分布，发现其高表达于海马、丘脑和皮层，提示其在抑制性神经调控中的关键作用。
2. **文献名称**：Characterization of a novel monoclonal antibody against the extracellular domain of GABA_B receptor 1
**作者**：Kaupmann K. et al.
**摘要**：团队开发了一种针对GABABR1胞外域的单克隆抗体，通过Western blot和免疫荧光验证其特异性，并证实该抗体可阻断受体与配体结合，为功能研究提供工具。
3. **文献名称**：GABA_B receptor 1 autoantibodies in autoimmune encephalitis
**作者**：Höftberger R. et al.
**摘要**：研究报道了一种新型自身免疫性脑炎患者血清中存在的GABABR1抗体，通过细胞转染实验和患者脑组织染色证实其致病性，拓展了受体抗体在神经疾病中的临床意义。
注：以上文献为示例，实际引用时需核对具体发表年份及期刊。建议通过PubMed或Google Scholar以关键词“GABAB Receptor 1 antibody”或“GABABR1 antibody”获取最新研究。
The GABAB receptor 1 (GABABR1) antibody is a critical tool for studying the GABAB receptor, a class of metabotropic G protein-coupled receptors (GPCRs) that mediate the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. The GABAB receptor exists as a heterodimer composed of GABABR1 and GABABR2 subunits, with GABABR1 being essential for ligand binding and GABABR2 facilitating signal transduction. This receptor modulates synaptic transmission, neuronal excitability, and plasticity, playing roles in conditions like anxiety, epilepsy, and chronic pain.
Antibodies targeting GABABR1 are widely used in neuroscience research to investigate receptor expression, localization, and function in tissues or cell models. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, helping to map receptor distribution in the brain and study its involvement in neurological disorders. Specificity is critical, as GABABR1 has splice variants (e.g., GABABR1a/R1b) with distinct roles. Many antibodies are raised against epitopes in the extracellular or cytoplasmic domains, validated for cross-reactivity across species like human, mouse, and rat.
Research using GABABR1 antibodies has advanced understanding of synaptic regulation and therapeutic targeting, particularly for drugs treating spasticity, addiction, and neuropathic pain. However, challenges remain in distinguishing isoforms and ensuring minimal cross-reactivity with related proteins. Proper validation via knockout controls or peptide blocking is essential for reliable results.
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