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Rabbit Monoclonal HLA-DQA1 Antibody

  • 中文名： HLA-DQA1抗体
  • 别    名： HLA-DQA1; CD; CELIAC1; DQ-A1; GSE; HLA-DQA; DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1;;HLA DQA1
货号: IPDX17700
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHLA-DQA1; CD; CELIAC1; DQ-A1; GSE; HLA-DQA; DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1;;HLA DQA1
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human HLA DQA1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于HLA-DQA1抗体的3篇模拟参考文献示例(实际文献需通过学术数据库核实)：

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1. **文献名称**：*HLA-DQA1 Antibodies in Celiac Disease: Diagnostic and Pathogenic Implications*

**作者**：Sollid LM, et al.

**摘要**：探讨HLA-DQA1抗体在乳糜泻患者中的特异性表达，分析其与组织转谷氨酰胺酶抗体的关联性，揭示HLA-DQA1等位基因变异如何通过分子模拟机制触发自身免疫反应。

2. **文献名称**：*Role of HLA Class II Antibodies in Kidney Transplant Rejection*

**作者**：Tambur AR, et al.

**摘要**：研究HLA-II类抗体(包括DQA1/DQB1)在肾移植排斥中的作用，发现DQA1抗体可通过激活内皮细胞炎症通路加剧抗体介导的排斥反应，强调移植前配型中检测II类抗体的必要性。

3. **文献名称**：*HLA-DQA1 Epitope Mapping and Antibody Binding Dynamics*

**作者**：Dai S, et al.

**摘要**：通过晶体结构分析和体外结合实验，解析HLA-DQA1蛋白的抗原表位特征，阐明特定抗体结合区域及其对T细胞激活的影响，为靶向免疫治疗提供结构基础。

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**建议**：以上为示例，实际文献请通过PubMed、Google Scholar等平台检索关键词(如"HLA-DQA1 antibody"、"HLA-DQA1 autoimmunity")，并优先选择近5年发表的高被引论文或权威期刊(如*Frontiers in Immunology*, *Human Immunology*)。

背景信息

HLA-DQA1 antibodies target the alpha chain of the HLA-DQ heterodimer, a class II major histocompatibility complex (MHC) molecule encoded by the HLA-DQA1 gene. These molecules are critical for immune regulation, as they present exogenous peptide antigens to CD4+ T cells to initiate adaptive immune responses. HLA-DQ molecules consist of an α-chain (HLA-DQA1) and a β-chain (HLA-DQB1), both of which exhibit high polymorphism, influencing antigen-binding specificity and disease susceptibility. Antibodies against HLA-DQA1 are less commonly studied compared to those targeting HLA-DQβ or HLA-DR, but they hold clinical significance in transplantation and autoimmune disorders. In organ transplantation, preformed or de novo HLA-DQA1 antibodies may contribute to graft rejection by triggering complement activation or antibody-dependent cellular cytotoxicity. Additionally, certain HLA-DQA1 alleles are strongly associated with autoimmune conditions like celiac disease (e.g., DQA1*05:01) and type 1 diabetes (e.g., DQA1*03:01), where autoantibodies may arise against tissue-specific antigens in genetically predisposed individuals. Research also explores HLA-DQA1 antibodies as potential biomarkers for disease risk stratification or therapeutic monitoring. However, their detection and interpretation remain technically challenging due to the complexity of HLA-DQ epitopes and cross-reactivity with other HLA class II molecules. Advances in epitope mapping and high-resolution HLA typing continue to refine understanding of their pathophysiological roles.

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