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Rabbit Monoclonal GLUR Antibody

  • 中文名： GLUR抗体
  • 别    名： GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase, mitochondrial; GR; Gr1; GRase; GRD1; GSR; ;Glutathione reductase
货号: IPDX17697
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase, mitochondrial; GR; Gr1; GRase; GRD1; GSR; ;Glutathione reductase
WB Predicted band size56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Glutathione reductase
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于谷氨酸受体(GLUR)抗体的代表性文献(虚构示例，仅供参考格式)：

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1. **文献名称**: *Antibody-specific detection of GluA2 subunits in synaptic plasticity*

**作者**: Smith A, Huganir R

**摘要**: 本研究使用特异性GluA2抗体，证实AMPA受体亚基GluA2在突触长时程抑制(LTD)中的动态变化，揭示了磷酸化修饰对突触定位的调控机制。

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2. **文献名称**: *GluN1 antibody reveals developmental changes in NMDA receptor expression*

**作者**: Lee C, Sheng M

**摘要**: 通过GluN1特异性抗体分析小鼠脑发育不同阶段的NMDA受体分布，发现其表达水平与神经元成熟及突触可塑性密切相关。

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3. **文献名称**: *AMPA receptor antibodies in Alzheimer's disease models*

**作者**: Dingledine R, Borges K

**摘要**: 采用GluA1/GluA3抗体检测阿尔茨海默病模型脑组织中AMPA受体亚型的异常聚集，提示其与认知功能障碍的潜在关联。

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4. **文献名称**: *Characterization of anti-GluR5-7 antibodies for kainate receptor studies*

**作者**: Bettler B, et al.

**摘要**: 报道针对kainate受体亚型GluR5-7的单克隆抗体制备及验证，证明其在免疫印迹和免疫组化中具有高特异性。

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(注：以上文献信息为示例性质，实际引用请通过PubMed或学术数据库检索真实文献)

背景信息

Glutamate receptors (GluRs) are critical neurotransmitter receptors in the central nervous system, mediating excitatory synaptic transmission. They are broadly categorized into ionotropic (iGluRs) and metabotropic (mGluRs) receptors. iGluRs, including NMDA, AMPA, and kainate subtypes, are ligand-gated ion channels essential for synaptic plasticity, learning, and memory. mGluRs are G protein-coupled receptors modulating synaptic activity and neuronal communication. Antibodies targeting GluRs are vital tools in neuroscience research, enabling the localization, quantification, and functional analysis of these receptors in tissues or cultured cells. For example, anti-AMPA receptor antibodies help study their role in long-term potentiation, while anti-NMDA receptor antibodies are used to investigate neurological disorders like schizophrenia or epilepsy. Clinically, autoantibodies against GluRs (e.g., anti-NMDA receptor antibodies) are biomarkers for autoimmune encephalitis, aiding diagnosis and treatment. Researchers also utilize GluR antibodies to explore pathological mechanisms in neurodegenerative diseases, such as Alzheimer’s, where receptor dysregulation is implicated. These antibodies are typically validated via techniques like immunohistochemistry, western blotting, or electrophysiology to ensure specificity and reliability. Their application advances both basic understanding of neural circuits and therapeutic development for neurological and psychiatric conditions.

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