| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | B-50; PP46 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GAP43 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ORM1抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*Autoantibodies against ORM1 in patients with systemic lupus erythematosus*
**作者**：Li Y, et al.
**摘要**：该研究发现系统性红斑狼疮(SLE)患者血清中存在针对ORM1的自身抗体，提示ORM1可能作为自身抗原参与疾病进展。抗体水平与疾病活动度相关，可能成为潜在生物标志物。
2. **文献名称**：*Proteomic identification of ORM1 as a target of autoantibodies in hepatocellular carcinoma*
**作者**：Wang X, et al.
**摘要**：通过蛋白质组学分析，发现肝细胞癌患者中ORM1抗体显著升高，可能与肿瘤免疫逃逸相关。研究认为ORM1抗体可能用于肝癌的早期诊断或疗效监测。
3. **文献名称**：*Anti-ORM1 antibodies in rheumatoid arthritis: Association with joint inflammation*
**作者**：Kurokawa R, et al.
**摘要**：探讨类风湿关节炎(RA)患者中ORM1抗体的临床意义，发现其与关节炎症程度呈正相关，提示抗体可能通过调控炎症因子加剧病理过程。
4. **文献名称**：*ORM1 as a novel biomarker for sepsis: Insights from antibody-mediated immune profiling*
**作者**：Zhang L, et al.
**摘要**：研究显示，脓毒症患者ORM1抗体水平显著变化，可能通过影响免疫细胞信号通路参与脓毒症炎症风暴，为预后评估提供新方向。
---
注：以上文献信息为模拟示例，实际引用需根据具体研究核实。建议通过PubMed或Web of Science以“ORM1 antibody”或“Anti-ORM1 autoantibody”为关键词检索最新文献。
ORM1 (Orosomucoid 1) antibody targets the ORM1 protein, also known as alpha-1-acid glycoprotein (AGP), a key acute-phase reactant synthesized primarily in the liver. ORM1 is a member of the immunocalin family, characterized by its high carbohydrate content (45%) and low molecular weight (41-43 kDa). It plays a role in immune modulation, binding to drugs (e.g., steroids, antivirals) to influence their pharmacokinetics, and regulating vascular permeability during inflammation.
ORM1 levels rise significantly during acute-phase responses triggered by infection, trauma, or chronic conditions like cancer or autoimmune diseases. Antibodies against ORM1 are widely used in research and diagnostics to quantify its expression in serum or tissues, aiding in studies of inflammatory pathways, drug resistance, and disease progression. For instance, elevated ORM1 correlates with poor prognosis in cancers and drug inefficacy due to its drug-binding properties.
Commercially available ORM1 antibodies are typically monoclonal or polyclonal, validated for techniques like ELISA, Western blot, or immunohistochemistry. Structural studies highlight its five N-linked glycosylation sites and two lipocalin domains, which are critical for antibody specificity. Recent interest focuses on ORM1's dual role in pro- and anti-inflammatory processes, making its antibodies valuable tools for unraveling its context-dependent functions in pathophysiology.
×
