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Rabbit Monoclonal SERPINC1 Antibody

  • 中文名： SERPINC1抗体
  • 别    名： Antithrombin; Antithrombin III; AT 3; AT III; AT3; AT3D; ATIII; Heparin cofactor I; Serpin C1; Serpin family C member 1; SERPINC1; THPH7;;Antithrombin 3
货号: IPDX17673
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAntithrombin; Antithrombin III; AT 3; AT III; AT3; AT3D; ATIII; Heparin cofactor I; Serpin C1; Serpin family C member 1; SERPINC1; THPH7;;Antithrombin 3
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Antithrombin 3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SERPINC1抗体的3篇示例参考文献(注：文献为示例，实际引用需核实):

1. **文献名称**: "Functional characterization of SERPINC1 mutations in hereditary antithrombin deficiency"

**作者**: Olds RJ, et al.

**摘要**: 通过SERPINC1抗体进行Western blot和ELISA分析，揭示了遗传性抗凝血酶缺乏症患者中SERPINC1基因突变的致病机制，发现突变导致抗凝血酶-III(AT-III)分泌异常或结构稳定性下降。

2. **文献名称**: "Development of a monoclonal antibody-based ELISA for detecting plasma antithrombin levels"

**作者**: Luxembourg B, et al.

**摘要**: 研究开发了一种高特异性SERPINC1单克隆抗体，用于定量检测人血浆中AT-III水平，验证了其在血栓性疾病诊断中的敏感性和临床适用性，并与传统活性检测法对比分析。

3. **文献名称**: "Structural analysis of antithrombin-III using epitope-specific antibodies"

**作者**: Gettins PG, et al.

**摘要**: 利用针对SERPINC1不同表位的抗体研究AT-III的构象变化，揭示了肝素结合域和反应中心环的结构动态变化如何影响其抗凝功能，为突变相关功能缺陷提供结构生物学依据。

**提示**：实际研究中建议通过PubMed/Google Scholar以关键词“SERPINC1 antibody”、“antithrombin III immunoassay”检索最新文献，重点关注抗体在疾病诊断(如遗传性血栓倾向)或蛋白功能研究中的应用。

背景信息

The SERPINC1 gene encodes antithrombin, a key serine protease inhibitor that regulates blood coagulation by inactivating thrombin and factor Xa. Deficiencies in antithrombin, caused by SERPINC1 mutations, are linked to hereditary thrombophilia, increasing risks of venous thromboembolism. Antibodies targeting SERPINC1 or its protein product are essential tools in research and diagnostics. In research, they help quantify antithrombin levels, study its structural and functional properties, and investigate mechanisms of thrombosis or rare mutations affecting protein stability. Diagnostically, these antibodies aid in identifying antithrombin deficiency via immunoassays like ELISA or Western blot, differentiating between type I (reduced levels) and type II (dysfunctional protein) deficiencies. Clinically, antithrombin replacement therapy, guided by antibody-based assays, is used to manage severe deficiencies. Some antibodies also detect post-translational modifications (e.g., glycosylation) critical for antithrombin’s activity. Challenges include distinguishing between functional and non-functional antithrombin forms and ensuring assay standardization. Overall, SERPINC1 antibodies bridge molecular insights into coagulation disorders with practical applications in patient care and therapeutic development.

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