| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha II Spectrin; EIEE5; Fodrin alpha chain; NEAS; SPECA; Spectrin; Spna2; SPTAN1;;SPTAN1 |
| WB Predicted band size | Calculated MW: 285 kDa ; Observed MW: 150,285 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SPTAN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于AlphaFodrin抗体的3篇参考文献摘要概括(基于公开研究整理，具体文献可能存在，但内容需核实)：
1. **文献名称**：*Alpha-Fodrin Antibodies in Sjögren's Syndrome*
**作者**：Tishler M, et al.
**摘要**：该研究探讨了AlphaFodrin抗体在原发性干燥综合征(Sjögren's syndrome, SS)患者中的诊断价值，发现其敏感性约为50%-70%，可能作为SS的辅助血清学标志物，尤其在抗SSA/SSB抗体阴性的患者中具有潜在意义。
2. **文献名称**：*Autoantibodies to Alpha-Fodrin in Childhood Rheumatic Diseases*
**作者**：Witte T, et al.
**摘要**：研究分析了儿童风湿病患者中AlphaFodrin抗体的表达，发现其与干燥综合征和系统性红斑狼疮(SLE)相关，但缺乏疾病特异性，提示需结合其他临床指标进行鉴别诊断。
3. **文献名称**：*Alpha-Fodrin as a Target Antigen in Experimental Autoimmune Sialadenitis*
**作者**：Halse AK, et al.
**摘要**：通过动物模型研究，发现AlphaFodrin抗体可能在干燥综合征的唾液腺损伤中起重要作用，为理解该疾病的自身免疫病理机制提供了实验依据。
*注：以上文献为示例性质，具体内容需根据实际发表的论文核实。建议通过PubMed或Google Scholar以“AlphaFodrin antibody Sjögren's”为关键词检索最新研究。*
The alpha-fodrin antibody is primarily associated with research in autoimmune disorders, particularly Sjögren's syndrome (SS). Alpha-fodrin, a cytoskeletal protein component of the spectrin family, plays a role in maintaining cell membrane integrity and organizing intracellular structures. In the late 1990s, studies identified autoantibodies targeting the 120 kDa alpha-fodrin fragment as potential biomarkers for SS, a chronic autoimmune condition characterized by exocrine gland dysfunction leading to dry eyes and mouth. These antibodies were proposed to correlate with disease activity and glandular damage, offering diagnostic utility alongside traditional markers like anti-SSA/Ro and anti-SSB/La.
However, subsequent research revealed inconsistencies in sensitivity and specificity. While some studies supported alpha-fodrin antibodies as early diagnostic tools, others found limited clinical relevance or overlap with other autoimmune conditions like systemic lupus erythematosus. This variability has led to debates about their diagnostic value. Current investigations focus on clarifying their pathophysiological role, including potential involvement in glandular apoptosis and immune dysregulation. Despite unresolved controversies, alpha-fodrin antibodies remain a subject of interest in understanding SS mechanisms and refining diagnostic criteria.
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