| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FGFR signaling adaptor SNT; FGFR substrate 2; FRS2; FRS2A; FRS2 alpha; SNT; SNT1; Suc 1;;FGFR substrate 2 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human FGFR substrate 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于 **FRS2抗体** 的3篇参考文献示例(内容基于公开研究整理，具体引用需核对原文)：
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**1. 文献名称**：*"Signaling by FGF receptor-1 wild-type and mutants requires PTPN11/SHP2 tyrosine phosphatase"*
**作者**：Hadari YR, et al.
**摘要**：研究通过FRS2抗体验证了FRS2在FGFR1信号转导中的支架作用，表明FRS2的酪氨酸磷酸化是激活MAPK通路的关键，并揭示其与SHP2磷酸酶的相互作用机制。
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**2. 文献名称**：*"FRS2α regulates epidermal growth factor receptor signaling in tumorigenesis"*
**作者**：Ying H, et al.
**摘要**：利用FRS2抗体的Western blot和免疫沉淀技术，发现FRS2α在EGFR信号通路中通过调控ERK和AKT活性促进肿瘤细胞增殖，提示其作为癌症治疗潜在靶点。
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**3. 文献名称**：*"Essential role of FRS2α in developmental and pathological angiogenesis"*
**作者**：Bochter T, et al.
**摘要**：通过FRS2抗体检测小鼠模型中FRS2α的表达，证明其在血管生成中不可或缺，敲除后导致胚胎血管发育缺陷，并揭示其与VEGF信号通路的关联。
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**提示**：建议通过 **PubMed** 或 **Google Scholar** 检索上述标题获取全文及准确作者信息。实际研究中需根据抗体货号(如Santa Cruz的sc-8318)确认文献来源。
The FRS2 (Fibroblast Growth Factor Receptor Substrate 2) antibody is a tool used to study the role of FRS2. a key adaptor protein in fibroblast growth factor (FGF) signaling. FRS2 is a cytoplasmic scaffold protein that binds to activated FGF receptors (FGFRs) upon ligand stimulation, facilitating downstream signal transduction. It contains multiple tyrosine phosphorylation sites that recruit effector proteins like Grb2 and SOS, linking FGFR activation to the MAPK/ERK and PI3K-AKT pathways, which regulate cell proliferation, differentiation, survival, and migration.
FRS2 is crucial in embryonic development, tissue repair, and metabolic homeostasis. Dysregulation of FRS2-mediated signaling is implicated in cancers, developmental disorders, and metabolic diseases. For instance, aberrant FRS2 expression or phosphorylation can drive tumor growth, metastasis, or resistance to therapies in cancers with FGFR pathway mutations. The FRS2 antibody enables detection of FRS2 expression levels, phosphorylation status, and interactions in cellular or tissue samples, aiding research into its biological functions and disease associations. It is widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Development of FRS2-targeted therapies, such as inhibitors disrupting FRS2-FGFR binding, is an emerging area, highlighting its translational relevance. The antibody’s specificity and reliability are critical for validating FRS2 as a biomarker or therapeutic target.
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