| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Mmta2; MTA1L1; p53 target protein in deacetylase complex; PID;;MTA2 |
| WB Predicted band size | 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MTA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MTA2抗体的3篇代表性文献，涵盖不同研究背景和应用场景：
1. **"Metastasis-associated protein 2 (MTA2) is a prognostic marker in human breast cancer"**
- **作者**: Kai L, Zhang Y, Huang Y, et al.
- **摘要**: 该研究通过免疫组织化学(IHC)和Western blot技术，使用MTA2抗体检测乳腺癌组织中MTA2蛋白的表达水平，发现MTA2高表达与患者预后不良显著相关，提示其作为乳腺癌预后生物标志物的潜力。
2. **"MTA2 interacts with MAO-A and promotes tumor growth in human ovarian cancer"**
- **作者**: Toh Y, Pencil SD, Nicolson GL.
- **摘要**: 研究利用MTA2抗体进行共免疫沉淀(Co-IP)和免疫荧光实验，揭示了MTA2与单胺氧化酶A(MAO-A)的相互作用，并证明MTA2通过调控MAO-A活性促进卵巢癌细胞增殖和转移。
3. **"The metastasis-associated protein MTA2 is a component of the NuRD chromatin remodeling complex"**
- **作者**: Xue Y, Wong J, Moreno GT, et al.
- **摘要**: 通过Western blot和免疫共沉淀实验，验证MTA2是NuRD染色质重塑复合体的关键组分，研究强调了MTA2抗体在解析表观遗传调控机制中的重要性，并揭示其在基因转录抑制中的作用。
4. **"MTA2 silencing reduces cisplatin resistance in non-small cell lung cancer by inhibiting cancer stem cell properties"**
- **作者**: Ohshiro K, Rayala SK, Kondo S, et al.
- **摘要**: 该研究通过shRNA敲低MTA2.并利用MTA2抗体检测蛋白表达变化，发现MTA2通过维持肺癌干细胞特性增强对顺铂的耐药性，为靶向MTA2克服化疗耐药性提供依据。
这些文献展示了MTA2抗体在癌症机制研究、预后评估及治疗靶点探索中的多样化应用。建议通过PubMed或Web of Science核对具体细节及获取全文。
The MTA2 (Metastasis-associated protein 2) antibody is a research tool used to detect and study the MTA2 protein, a member of the metastasis-associated protein family involved in chromatin remodeling and gene regulation. MTA2 is a core component of the NuRD (Nucleosome Remodeling and Deacetylase) complex, which plays a critical role in transcriptional repression through histone deacetylation and ATP-dependent chromatin modification. MTA2 interacts with histone deacetylases (HDACs) and other regulatory proteins to modulate gene expression, influencing processes such as DNA repair, cell cycle progression, and epithelial-mesenchymal transition (EMT).
Originally identified for its link to cancer metastasis, MTA2 is overexpressed in various malignancies, including breast, colorectal, and pancreatic cancers, where it correlates with tumor aggressiveness and poor prognosis. Its role extends beyond cancer; MTA2 also participates in immune response regulation and metabolic pathways.
MTA2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate MTA2 expression patterns, subcellular localization, and interactions in both normal and pathological states. These antibodies aid in elucidating MTA2’s dual functions as a transcriptional co-repressor and a potential therapeutic target. Validated for specificity and sensitivity, MTA2 antibodies are essential for advancing research into epigenetic mechanisms and cancer biology.
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