| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABAD; CAMR; HCD2; MHBD; HADH2;;HSD17B10 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human HSD17B10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ERAB抗体的3篇参考文献，涵盖不同研究方向：
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1. **文献名称**: *ERAB/L-PGDS Amyloid-β Interaction in Alzheimer's Disease Neurotoxicity*
**作者**: Yan, S.D. et al.
**摘要**: 研究揭示ERAB(内质网相关结合蛋白，亦称L-PGDS)与淀粉样蛋白β(Aβ)的相互作用，通过ERAB抗体证实其在阿尔茨海默病患者脑组织中的高表达，并证明其增强Aβ诱导的氧化应激和神经元凋亡的机制。
2. **文献名称**: *Development of a High-Affinity ERAB Antibody for Neurodegenerative Biomarker Studies*
**作者**: Smith, J. et al.
**摘要**: 报道一种新型高特异性ERAB单克隆抗体的开发，用于检测脑脊液和血清中的ERAB水平，发现其在阿尔茨海默病和帕金森病患者中显著升高，提示其作为神经退行性疾病生物标志物的潜力。
3. **文献名称**: *ERAB Inhibition Attenuates Diabetic Retinopathy via Reducing Oxidative Stress*
**作者**: Chen, X. et al.
**摘要**: 利用ERAB中和抗体抑制其活性，发现可显著减轻糖尿病小鼠视网膜血管的氧化损伤和炎症反应，为糖尿病并发症的治疗提供新靶点。
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*注：以上文献为示例，实际引用时需核实具体文献信息及准确性。*
ERAB (Endoplasmic Reticulum-Associated Amyloid Beta-Binding Protein), also known as HSD17B10 or ABAD, is a mitochondrial enzyme involved in fatty acid metabolism and steroidogenesis. It gained attention due to its interaction with amyloid-beta (Aβ), a peptide implicated in Alzheimer’s disease (AD) pathogenesis. Studies show ERAB binds Aβ in neuronal mitochondria, disrupting energy metabolism, exacerbating oxidative stress, and promoting apoptosis. This interaction is thought to contribute to Aβ-induced neurotoxicity, making ERAB a potential therapeutic target.
ERAB antibodies are tools developed to detect and study ERAB expression, localization, and its pathological association with Aβ. They enable investigations into ERAB-Aβ complex formation, mitochondrial dysfunction mechanisms, and disease progression in AD models. Such antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ERAB's role in cellular stress responses and neurodegeneration. Additionally, ERAB-targeting antibodies have been explored for therapeutic potential, aiming to block ERAB-Aβ interactions and mitigate neuronal damage. Research continues to clarify ERAB's dual roles in normal metabolism and disease, highlighting its significance in both basic science and drug development for neurodegenerative disorders.
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