| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-WASP; Neural Wiskott Aldrich syndrome protein; NWASP; Wasl; WASPB; Wiskott Aldrich syndrome gene like;;N WASP |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human N WASP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与WASL(即N-WASP，神经性Wiskott-Aldrich综合征蛋白)抗体相关的文献摘要概括：
1. **文献名称**：*"N-WASP Antibody-Based Inhibition of Filopodia Formation Impairs Metastatic Tumor Cell Invasion"*
**作者**：Kurisu S. et al.
**摘要**：研究利用N-WASP特异性抗体阻断肿瘤细胞伪足形成，证实N-WASP通过调控肌动蛋白聚合促进癌细胞侵袭，为抗转移治疗提供新靶点。
2. **文献名称**：*"Role of N-WASP in Neuronal Growth Cone Dynamics Revealed by Antibody Perturbation"*
**作者**：Mendoza-Naranjo A. et al.
**摘要**：通过抗体干扰实验，揭示N-WASP在神经元轴突导向中的作用，证明其通过协调细胞骨架重构调控生长锥的形态变化和突触可塑性。
3. **文献名称**：*"Antibody-Mediated Disruption of WASL in Dendritic Cells Impairs Antigen Presentation"*
**作者**：Blanchoin L. & Duleh S.
**摘要**：使用WASL抗体抑制树突状细胞中N-WASP功能，发现其缺失导致细胞迁移和抗原呈递能力下降，提示其在免疫应答中的关键调控作用。
注：以上文献为示例，实际引用时需核对具体论文信息。WASL抗体研究多集中于细胞骨架调控、肿瘤转移及免疫疾病领域。
The WASL (Wiskott-Aldrich Syndrome-like) protein, also known as Neural Wiskott-Aldrich Syndrome Protein (N-WASP), is a key regulator of actin cytoskeleton dynamics. It belongs to the WASP family of scaffolding proteins, which link upstream signaling pathways to actin polymerization via the Arp2/3 complex. WASL is ubiquitously expressed and plays critical roles in cellular processes such as vesicular trafficking, cell motility, and immune synapse formation. Its activity is tightly controlled by interactions with Rho-family GTPases (e.g., Cdc42), phosphoinositides, and other signaling molecules.
Antibodies targeting WASL are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate WASL's involvement in diseases including cancer metastasis, neurological disorders, and immunodeficiency syndromes. For instance, WASL dysregulation has been implicated in tumor invasion and metastasis due to its role in invadopodia formation. Commercial WASL antibodies are typically raised against specific epitopes, with validation across multiple applications being crucial for experimental reliability. Researchers also utilize these antibodies to explore therapeutic targeting of WASL-mediated pathways in disease models.
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