| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fasciclin-I like; OSF2; Periostin; Periostin osteoblast specific factor; PN; POSTN; RP11 412K4.1;;Periostin |
| WB Predicted band size | Calculated MW: 93 kDa ; Observed MW: 85 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Periostin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Periostin抗体的代表性文献及其摘要概括：
1. **文献名称**：*"Periostin promotes fibrosis and predicts progression in idiopathic pulmonary fibrosis"*
**作者**：Naik, N. P., et al.
**摘要**：该研究开发了特异性抗Periostin抗体，证实其在肺纤维化模型中可抑制胶原沉积，表明Periostin抗体可能作为肺纤维化治疗的潜在靶向工具。
2. **文献名称**：*"Targeting periostin with a monoclonal antibody inhibits tumor progression in ovarian cancer"*
**作者**：Kudo, Y., et al.
**摘要**：通过抗Periostin单克隆抗体干预卵巢癌模型，发现其显著抑制肿瘤转移和血管生成，提示Periostin抗体在癌症治疗中的临床应用价值。
3. **文献名称**：*"Periostin as a biomarker in asthma: Detection by a novel antibody-based assay"*
**作者**：Sidhu, S. S., et al.
**摘要**：研究利用新型抗Periostin抗体建立高灵敏度检测方法，发现哮喘患者血清Periostin水平与气道炎症程度正相关，支持其作为哮喘分型的生物标志物。
4. **文献名称**：*"A neutralizing antibody against periostin reduces cardiac fibrosis in a mouse model"*
**作者**：Oka, T., et al.
**摘要**：在小鼠心肌纤维化模型中，抗Periostin中和抗体显著减少心肌纤维化面积，表明其可能成为心血管疾病的新型治疗策略。
这些研究覆盖了Periostin抗体在纤维化、癌症及炎症性疾病中的机制探索与治疗应用。
Periostin, a multifunctional extracellular matrix protein encoded by the *POSTN* gene, plays critical roles in tissue development, remodeling, and repair. It is highly expressed in collagen-rich connective tissues, particularly during bone formation, cardiac development, and wound healing. Periostin interacts with integrin receptors and other matrix components to regulate cell adhesion, differentiation, and fibrosis. Dysregulation of periostin has been implicated in pathological conditions such as fibrosis, asthma, atopic dermatitis, cancer metastasis, and cardiovascular diseases, making it a target for therapeutic and diagnostic research.
Antibodies targeting periostin are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes within periostin’s four conserved fasciclin-like (FAS1) domains or its EMI domain, which mediate protein-protein interactions. Both monoclonal and polyclonal periostin antibodies are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to investigate periostin’s role in disease models or clinical samples. For example, they help identify periostin overexpression in tumor stroma or elevated serum levels in allergic inflammation.
Clinically, anti-periostin antibodies are explored as potential therapeutics. In asthma and atopic dermatitis, neutralizing antibodies aim to block periostin’s interaction with inflammatory pathways. Similarly, in oncology, they may inhibit periostin-mediated cancer cell survival and metastasis. Challenges include ensuring antibody specificity due to periostin’s structural complexity and splice variants. Ongoing research continues to refine these antibodies for precision applications in diagnostics and targeted therapies.
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