| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSPB6; HEL55; Hsp20; Heat-shock 20 kDa like-protein p20;;Hsp20 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Hsp20 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Hsp20抗体的3篇参考文献(信息基于公开文献概括，非真实引用，仅供示例参考)：
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1. **文献名称**：*Hsp20 protects against oxidative stress in cardiomyocytes via AKT/GSK3β signaling*
**作者**：Smith A, et al.
**摘要**：研究利用Hsp20特异性抗体检测其在心肌细胞中的表达，发现Hsp20通过激活AKT/GSK3β通路减轻氧化应激损伤，抗体用于Western blot和免疫荧光验证蛋白定位。
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2. **文献名称**：*Differential expression of Hsp20 in colorectal cancer and its clinical significance*
**作者**：Zhang Y, et al.
**摘要**：通过Hsp20抗体进行免疫组化分析，发现Hsp20在结直肠癌组织中表达显著下调，低表达与患者预后不良相关，提示其可能作为肿瘤抑制因子。
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3. **文献名称**：*Validation of a novel monoclonal antibody for Hsp20 in neurodegenerative models*
**作者**：Lee C, et al.
**摘要**：研究报道了一种新型Hsp20单克隆抗体的开发，验证其在阿尔茨海默病小鼠模型中的特异性，证实Hsp20在神经元中的应激保护作用。
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如需具体文献，建议通过PubMed或Web of Science以“Hsp20 antibody”或“HSPB6 antibody”为关键词检索。
**Background of Hsp20 Antibody**
Heat shock protein 20 (Hsp20), a member of the small heat shock protein (sHSP) family, is a molecular chaperone that plays a critical role in cellular stress responses. It assists in protein folding, prevents aggregation of denatured proteins, and supports cell survival under stress conditions such as heat, oxidative stress, or ischemia. Hsp20 is particularly notable for its cardioprotective functions, including modulation of apoptosis, contractility, and vascular smooth muscle relaxation, making it a focus in cardiovascular research.
Hsp20 antibodies are essential tools for detecting and quantifying Hsp20 expression in tissues or cells. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study Hsp20's regulatory mechanisms, such as phosphorylation-dependent interactions. Research has linked Hsp20 dysregulation to pathologies like heart failure, neurodegenerative diseases, and cancer, positioning it as a potential biomarker or therapeutic target.
The antibody's specificity enables exploration of Hsp20's role in stress adaptation, disease mechanisms, and signaling pathways. Its high conservation across species also supports translational studies using animal models. By leveraging Hsp20 antibodies, scientists aim to uncover novel therapeutic strategies targeting Hsp20-associated pathways in human diseases.
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