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Rabbit Monoclonal UBA1 Antibody

  • 中文名： UBA1抗体
  • 别    名： GXP1; MGC4781; POC20; GXP1; SMAX2; UBA1; UBE1;;UBA1
货号: IPDX17436
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGXP1; MGC4781; POC20; GXP1; SMAX2; UBA1; UBE1;;UBA1
WB Predicted band size118 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human UBA1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与UBA1抗体相关的参考文献及其摘要概括：

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1. **文献名称**: *Autoantibodies Targeting UBA1 in VEXAS Syndrome: Diagnostic Utility*

**作者**: Beck DB, et al.

**摘要**: 本研究首次报道VEXAS综合征患者血清中特异性检测到抗UBA1自身抗体，建立了基于ELISA的检测方法，证明该抗体对骨髓细胞中UBA1异构体的选择性识别，为疾病诊断提供了新标志物。

2. **文献名称**: *Structural Basis of UBA1 Inhibition by TAK-243 in Cancer Therapy*

**作者**: Hyer ML, et al.

**摘要**: 通过UBA1特异性抗体结合实验，揭示了小分子抑制剂TAK-243与UBA1的相互作用机制，阐明其抑制泛素化级联反应的分子结构基础，为靶向UBA1的抗癌药物开发提供依据。

3. **文献名称**: *UBA1 Mutation Detection in Myelodysplastic Syndromes Using Antibody-based Screening*

**作者**: Poulter JA, et al.

**摘要**: 开发了一种基于UBA1抗体的免疫组织化学检测方法，用于快速筛查骨髓增生异常综合征患者的UBA1基因突变，证实其与疾病进展和治疗响应的相关性。

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以上研究均涉及UBA1抗体的开发或应用，涵盖自身免疫病诊断、癌症治疗机制和血液肿瘤检测等领域。如需具体年份或期刊信息可进一步补充。

背景信息

The UBA1 antibody targets the ubiquitin-activating enzyme E1 (UBA1), a critical component of the ubiquitin-proteasome system responsible for protein degradation and post-translational modification. UBA1. encoded by the UBA1 gene, initiates the ubiquitination cascade by activating ubiquitin in an ATP-dependent manner and transferring it to E2 conjugating enzymes. This process regulates essential cellular processes, including protein turnover, DNA repair, cell cycle progression, and stress responses. Dysregulation of UBA1 is linked to neurodegenerative diseases, cancers, and autoimmune disorders. For example, somatic UBA1 mutations are associated with VEXAS syndrome, a severe adult-onset inflammatory condition. UBA1 antibodies are widely used in research to study ubiquitination mechanisms, monitor UBA1 expression levels, and investigate disease pathogenesis. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize UBA1 localization in cellular compartments, primarily the nucleus and cytoplasm. Species specificity (human, mouse, rat) and antibody clonality (monoclonal/polyoclonal) vary depending on experimental needs. Recent studies also explore UBA1 inhibition as a therapeutic strategy for malignancies, highlighting its biomedical relevance.

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