| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IDDM5; SMT3H4; SUMO-4; dJ281H8.4;;SUMO 4 |
| WB Predicted band size | Calculated MW: 11 kDa ; Observed MW: 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SUMO 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于SUMO4抗体的参考文献，涵盖其功能、疾病关联及抗体应用：
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1. **文献名称**：*"SUMO4 Antibody Reveals a Critical Role in Cytokine Signaling and Autoimmunity"*
**作者**：Wang CY, et al.
**摘要**：该研究利用特异性SUMO4抗体，揭示了SUMO4通过调节IκBα的泛素化影响NF-κB信号通路，其基因多态性(M55V)与1型糖尿病风险相关。抗体检测显示SUMO4在免疫细胞中高表达，提示其在自身免疫疾病中的调控作用。
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2. **文献名称**：*"Characterization of SUMO4 Protein Expression and Localization Using Novel Monoclonal Antibodies"*
**作者**：Li J, et al.
**摘要**：研究团队开发了针对SUMO4的单克隆抗体，验证其特异性和灵敏度。通过免疫印迹和免疫荧光，发现SUMO4主要定位于细胞核，且在炎症刺激下表达上调，为研究SUMO4的翻译后修饰机制提供了工具。
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3. **文献名称**：*"SUMO4 Genetic Variants and Antibody-Mediated Detection in Diabetic Nephropathy"*
**作者**：Xu Q, et al.
**摘要**：通过SUMO4抗体检测糖尿病肾病患者组织样本，发现SUMO4在肾小球中的异常表达与疾病进展相关。研究指出SUMO4可能通过TGF-β通路促进纤维化，其抗体为临床病理分析提供了新标志物。
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4. **文献名称**：*"SUMO4 Antibody-Based Proteomic Analysis in Rheumatoid Arthritis Synovium"*
**作者**：Guo D, et al.
**摘要**：使用SUMO4抗体对类风湿关节炎滑膜组织进行蛋白质组学分析，发现SUMO4修饰蛋白在炎症和关节破坏中的关键作用，提示靶向SUMO4可能具有治疗潜力。
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这些文献展示了SUMO4抗体在机制研究、疾病关联分析及诊断工具开发中的应用。如需具体文章，建议通过PubMed或SciHub以标题/作者名检索全文。
SUMO4 (Small Ubiquitin-like Modifier 4) is a member of the SUMO protein family, which regulates post-translational modifications by covalently attaching to target proteins. This process, termed sumoylation, influences protein localization, stability, and interactions, thereby modulating cellular processes such as transcriptional regulation, stress responses, and immune signaling. SUMO4 shares structural similarities with other SUMO isoforms (SUMO1-3) but exhibits distinct expression patterns, predominantly in immune tissues like the spleen and kidneys. It has been implicated in autoimmune and inflammatory diseases, notably type 1 diabetes, due to its genetic association with susceptibility loci and its role in regulating NF-κB activity. A SUMO4 polymorphism (M55V) is linked to altered inflammatory responses, though its mechanistic impact remains debated.
SUMO4 antibodies are essential tools for studying its expression, localization, and function. They enable detection of SUMO4-conjugated proteins via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Researchers also use these antibodies to explore SUMO4's involvement in disease pathways, including diabetes, cancer, and neurodegeneration. Challenges in SUMO4 research include cross-reactivity with other SUMO isoforms due to high sequence homology, necessitating careful antibody validation. Despite this, SUMO4-specific antibodies continue to advance understanding of its unique biological roles and potential therapeutic targeting in inflammation-related disorders.
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