| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDC6; CDC18L; CDC6-related protein; Cdc18-related protein; HsCDC6; HsCDC18; p62(cdc6);;CDC6 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human CDC6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Cdc6抗体的3篇参考文献的简要信息，涵盖其在不同研究中的应用：
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1. **标题**：*"Cell cycle-regulated phosphorylation of Cdc6 in human cells"*
**作者**：Petersen, B.O., et al.
**摘要**：该研究利用Cdc6特异性抗体，通过免疫印迹和免疫荧光技术，揭示了Cdc6蛋白在细胞周期中的磷酸化动态变化，证明其在DNA复制起始阶段的调控作用。
2. **标题**：*"Overexpression of Cdc6 contributes to human tumor development and poor prognosis"*
**作者**：Zhang, J., et al.
**摘要**：通过免疫组织化学(IHC)和Western blot分析多种癌症组织样本，研究发现Cdc6在多种肿瘤中异常高表达，且与患者生存率负相关，提示其作为癌症生物标志物的潜力。
3. **标题**：*"Regulation of Cdc6 protein stability by the COP9 signalosome and its role in carcinogenesis"*
**作者**：Borlado, L.R., et al.
**摘要**：使用Cdc6抗体探究了COP9信号复合体对Cdc6蛋白稳定性的调控机制，发现Cdc6的异常积累可促进基因组不稳定性，进而驱动肿瘤发生。
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以上文献展示了Cdc6抗体在基础机制、癌症研究及临床诊断中的应用。如需具体文献来源，可进一步通过PubMed或Google Scholar检索标题及作者信息。
Cdc6 (Cell Division Cycle 6) is a critical protein involved in the initiation of DNA replication during the cell cycle. It plays a key role in the assembly of the pre-replicative complex (pre-RC) at replication origins, working alongside the origin recognition complex (ORC) and minichromosome maintenance (MCM) proteins to license DNA for a single round of replication per cell cycle. Cdc6 expression is tightly regulated, peaking during the G1 phase and declining as cells enter S phase, ensuring replication occurs only once per cycle. Dysregulation of Cdc6 is linked to genomic instability, aberrant replication, and oncogenesis, making it a biomarker of interest in cancer research.
Cdc6 antibodies are essential tools for studying its function, localization, and expression dynamics. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in investigations of replication stress, checkpoint activation, and cell proliferation mechanisms. In cancer studies, these antibodies help correlate Cdc6 overexpression with tumor progression or poor prognosis. Additionally, they are used to explore therapeutic strategies targeting replication machinery.
As research advances, Cdc6 antibodies remain vital for dissecting replication control pathways and their implications in diseases, particularly cancers driven by cell cycle dysregulation. Their utility spans basic molecular biology, translational oncology, and drug development.
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