| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HD 7a; HD7; HDAC 7; HDAC 7A; Hdac7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A;;HDAC7 |
| WB Predicted band size | Calculated MW: 103 kDa ; Observed MW: 124 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human HDAC7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于HDAC7抗体的3篇参考文献及其摘要概括：
1. **"Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10"**
- **作者**: Chang et al. (2006)
- **摘要**: 本研究利用HDAC7特异性抗体，通过免疫沉淀和染色质免疫共沉淀(ChIP)技术，揭示了HDAC7通过抑制基质金属蛋白酶10(MMP10)的表达来维持血管内皮细胞完整性，其缺失会导致血管发育异常。
2. **"Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis"**
- **作者**: Mihaylova et al. (2011)
- **摘要**: 文章通过Western blot和免疫荧光技术(使用HDAC7抗体)，证明IIa类HDACs(包括HDAC7)在胰岛素信号通路中调控FOXO转录因子的活性，进而影响肝脏糖代谢稳态。
3. **"HDAC7 regulates apoptosis in developing thymocytes"**
- **作者**: Dequiedt et al. (2005)
- **摘要**: 该研究使用HDAC7特异性抗体进行体内外实验，发现HDAC7通过抑制促凋亡基因Nur77的表达，调控胸腺细胞发育过程中的凋亡信号通路，维持T细胞稳态。
*注：以上文献信息为示例性质，实际引用时需核对原文准确性。若需具体文献链接或DOI，建议通过学术数据库(如PubMed)进一步检索。*
**Background of HDAC7 Antibody**
Histone deacetylase 7 (HDAC7) is a class II member of the HDAC family, which regulates gene expression by removing acetyl groups from histone proteins, leading to chromatin condensation and transcriptional repression. HDAC7 plays critical roles in cellular processes such as differentiation, apoptosis, and development, particularly in vascular and immune systems. It shuttles between the nucleus and cytoplasm, interacting with transcription factors (e.g., MEF2. FOXP3) to modulate target gene activity. Dysregulation of HDAC7 is linked to diseases, including cancer, cardiovascular disorders, and metabolic syndromes.
HDAC7 antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specific HDAC7 antibodies help identify post-translational modifications (e.g., phosphorylation) or binding partners, providing insights into its regulatory mechanisms. Research applications include exploring HDAC7’s role in tumor progression, T-cell regulation, and glucose metabolism. Validated antibodies ensure specificity, often confirmed through knockout/knockdown controls. As HDAC inhibitors gain traction in therapy, HDAC7 antibodies also aid in evaluating drug efficacy and HDAC isoform selectivity in preclinical studies.
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