| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Paired box protein Pax-9; PAX9;;PAX9 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PAX9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PAX9抗体的3篇代表性文献的简要概括(注：文献信息为示例性模拟，具体研究请通过学术数据库核实)：
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1. **文献名称**：*Pax9 is required for odontogenic differentiation and tooth development*
**作者**：Smith A, et al.
**摘要**：本研究利用PAX9特异性抗体，通过免疫组织化学技术揭示了PAX9在小鼠牙胚发育中的时空表达模式，证明其通过调控Bmp4等下游基因参与成牙本质细胞分化。
2. **文献名称**：*Aberrant PAX9 expression correlates with esophageal squamous cell carcinoma progression*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫荧光技术，发现PAX9抗体在食管鳞癌组织中高表达，且与患者预后不良相关，提示PAX9可能作为癌症生物标志物的潜在价值。
3. **文献名称**：*Validation of a novel PAX9 monoclonal antibody for embryonic studies*
**作者**：Johnson R, et al.
**摘要**：文章报道了一种高特异性PAX9单克隆抗体的开发与验证，通过敲除细胞系和胚胎切片染色证实其可靠性，为胚胎发育机制研究提供了重要工具。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“PAX9 antibody”+研究领域(如“tooth development”“cancer”等)，筛选近年的高被引论文。
The PAX9 antibody is a tool used to detect the paired box 9 (PAX9) protein, a transcription factor encoded by the *PAX9* gene. PAX9 belongs to the PAX family of genes, which play critical roles in embryonic development, particularly in organogenesis. Specifically, PAX9 is essential for the formation of teeth, craniofacial structures, and certain organs like the thymus and pancreas. It regulates gene expression during cell differentiation and tissue patterning, often interacting with signaling pathways such as BMP and FGF.
In research, PAX9 antibodies are widely utilized in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study protein expression and localization. These antibodies help elucidate PAX9’s role in developmental biology and diseases. Mutations in *PAX9* are linked to congenital conditions, such as tooth agenesis (missing teeth), and altered PAX9 expression has been observed in cancers, including oral squamous cell carcinoma and gastric cancer. Researchers also explore its potential as a biomarker or therapeutic target.
Commercially available PAX9 antibodies are typically monoclonal or polyclonal, validated for specificity and sensitivity across species (human, mouse, rat). Their applications span basic developmental studies, clinical diagnostics, and investigations into PAX9’s interplay with other regulatory molecules. However, variability in antibody performance across experimental conditions necessitates careful validation to ensure reproducibility in research findings.
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