| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CANDF7; ISGF 3 ; Signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; Stat1; STAT91; Transcription factor ISGF-3 components p91/p84;;STAT1 |
| WB Predicted band size | 87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human STAT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与STAT1α抗体相关的模拟参考文献示例(注：以下内容为示例性模拟，非真实文献，建议通过PubMed或Google Scholar查询真实文献)：
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1. **文献名称**: "Monoclonal antibody targeting STAT1α inhibits interferon-γ-mediated signaling in human cells"
**作者**: Müller M, et al.
**摘要**: 本研究开发了一种特异性识别STAT1α的单克隆抗体，证实其能够阻断IFN-γ诱导的STAT1磷酸化及下游基因表达，为自身免疫性疾病治疗提供了潜在工具。
2. **文献名称**: "Differential roles of STAT1α and STAT1β in immune responses revealed by a specific antibody panel"
**作者**: Chen L, et al.
**摘要**: 通过生成针对STAT1α和STAT1β异构体的特异性抗体，揭示了STAT1α在抗病毒先天免疫中的主导作用，而STAT1β可能通过负反馈调节炎症反应。
3. **文献名称**: "STAT1α gain-of-function mutations detected by phospho-specific antibody in chronic mucocutaneous candidiasis"
**作者**: Liu S, et al.
**摘要**: 利用针对STAT1α磷酸化位点的抗体，在慢性黏膜皮肤念珠菌病患者中鉴定了STAT1α功能获得性突变，揭示了其异常持续激活导致免疫失调的机制。
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建议通过PubMed等数据库检索真实文献(关键词：STAT1 alpha antibody, STAT1 phosphorylation, STAT1 isoforms)。
**Background of STAT1α Antibody**
The STAT1α antibody is a crucial tool in studying the Signal Transducer and Activator of Transcription 1 (STAT1) protein, specifically targeting its alpha isoform. STAT1. a member of the STAT family, plays a pivotal role in mediating cellular responses to cytokines, interferons (IFNs), and growth factors. It is activated via phosphorylation by Janus kinases (JAKs) upon ligand-receptor binding, leading to its dimerization, nuclear translocation, and regulation of target genes involved in immunity, proliferation, and apoptosis.
STAT1 exists in two isoforms: STAT1α (91 kDa) and STAT1β (84 kDa), generated by alternative splicing. STAT1α contains a C-terminal transactivation domain critical for full transcriptional activity, while STAT1β lacks this domain, often acting as a dominant-negative regulator. The STAT1α antibody specifically recognizes the α isoform, enabling researchers to distinguish between the two isoforms in studies of signaling dynamics.
This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate STAT1α's role in IFN signaling, antiviral responses, tumor suppression, and immune disorders. Dysregulation of STAT1α is linked to autoimmune diseases, immunodeficiency, and cancer, making the antibody essential for exploring disease mechanisms and therapeutic targets. Its specificity aids in elucidating isoform-specific functions, contributing to a deeper understanding of JAK-STAT pathway complexities.
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