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Rabbit Monoclonal ATF7 Antibody

  • 中文名: ATF7抗体
  • 别    名: Cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A; ATF7; ATFA;;ATF7
货号: IPDX17382
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A; ATF7; ATFA;;ATF7
WB Predicted band sizeCalculated MW: 52 kDa ; Observed MW: 53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human ATF7
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于ATF7抗体的3篇参考文献及其简要摘要:

1. **"ATF7-mediated histone H3K27 acetylation promotes esophageal squamous cell carcinoma progression"**

*Authors: Li X, Zhang Y, Liu Q, et al.*

摘要:该研究利用ATF7抗体通过ChIP-seq和免疫组化技术,揭示ATF7在食管鳞癌中通过调控组蛋白H3K27乙酰化促进肿瘤侵袭的机制,证实抗体在临床样本中的高表达与预后不良相关。

2. **"A novel monoclonal antibody against ATF7 efficiently blocks Toll-like receptor signaling pathways"**

*Authors: Tanaka S, Yamamoto M, Akira S.*

摘要:研究团队开发了一种新型ATF7单克隆抗体,验证其可特异性识别天然ATF7蛋白并抑制TLR触发的炎症反应,为免疫性疾病治疗提供潜在工具抗体。

3. **"Stress-induced nuclear translocation of ATF7 in hippocampal neurons: a study using subcellular fractionation and immunofluorescence"**

*Authors: Chen L, Wang H, Wei Z.*

摘要:通过ATF7抗体进行亚细胞分离和免疫荧光成像,发现氧化应激可诱导ATF7从胞质转位至海马神经元细胞核,调控应激相关基因转录,揭示了其在神经退行性疾病中的潜在作用。

注:上述文献信息为示例性质,实际文献需通过学术数据库核实。建议使用PubMed或Web of Science以“ATF7 antibody”为关键词检索最新研究。

背景信息

The ATF7 antibody is a crucial tool in studying the Activating Transcription Factor 7 (ATF7), a member of the ATF/CREB family of transcription factors. ATF7 plays a role in stress response, chromatin remodeling, and cellular adaptation by regulating target gene expression. It shares structural homology with other ATF proteins, featuring a basic leucine zipper (bZIP) domain for DNA binding and dimerization. Researchers use ATF7 antibodies to investigate its expression patterns, subcellular localization, and interactions in pathways like MAPK signaling. These antibodies are typically produced in hosts such as rabbits or mice, using immunogenic peptides derived from conserved regions of human ATF7. Validated for applications like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP), they help detect ATF7 in human, mouse, and rat samples. Specificity is confirmed through knockout controls or siRNA knockdowns. ATF7's involvement in diseases, including cancer and neurological disorders, underscores the antibody's importance in mechanistic studies. Recent studies highlight its role in epigenetic regulation under stress, making the antibody valuable for exploring gene-environment interactions. Commercial versions often include validation data from peer-reviewed publications to ensure reproducibility.

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