| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Histone H1.0; Histone H1(0); Histone H1.0, N-terminally processed; H1F0; H1FV; Histone H5;;Histone H1.0 |
| WB Predicted band size | Calculated MW: 21 kDa ; Observed MW: 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Histone H1.0 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Histone H1.0抗体的3篇参考文献示例(注：文献信息为模拟内容，实际需通过数据库验证)：
1. **文献名称**：*"Histone H1.0 is a key regulator of cellular differentiation through chromatin compaction"*
**作者**：Smith J, et al.
**摘要**：研究通过H1.0特异性抗体分析其在干细胞分化中的作用，发现H1.0通过调控染色质压缩影响基因表达，促进细胞命运转变。
2. **文献名称**：*"Antibody-based profiling of histone H1 variants in cancer progression"*
**作者**：Li X, Wang Y, et al.
**摘要**：利用H1.0抗体比较多种癌细胞中H1.0的表达水平，揭示其低表达与肿瘤转移和不良预后显著相关。
3. **文献名称**：*"Dynamic redistribution of histone H1.0 during DNA damage response"*
**作者**：Garcia-Perez R, et al.
**摘要**：通过免疫荧光(H1.0抗体)发现DNA损伤时H1.0从染色质解离并参与修复信号通路，提示其表观遗传调控功能。
建议通过 **PubMed** 或 **Google Scholar** 检索关键词“Histone H1.0 antibody”或“H1.0 chromatin antibody”获取真实文献。
Histone H1.0 is a linker histone protein that plays a critical role in organizing higher-order chromatin structure by binding to the DNA between nucleosomes. Unlike core histones (H2A, H2B, H3. H4), H1 variants regulate chromatin compaction and accessibility, influencing gene expression and epigenetic regulation. The H1.0 subtype is particularly associated with terminally differentiated cells and is often downregulated in proliferating or stem cells. Its expression dynamics are linked to cellular differentiation, tissue-specific functions, and diseases such as cancer, where aberrant H1.0 levels may correlate with tumor progression or suppression.
Antibodies targeting Histone H1.0 are essential tools for studying its localization, expression patterns, and functional roles. These antibodies are typically validated for applications like Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Researchers use them to investigate H1.0's involvement in chromatin remodeling, cellular differentiation, and disease mechanisms. For example, H1.0 antibodies have been employed to explore its tumor-suppressive role in certain cancers, where its loss may promote oncogenic plasticity.
Specificity is a key consideration, as the H1 family shares structural homology. High-quality H1.0 antibodies are rigorously tested to minimize cross-reactivity with other H1 variants (e.g., H1.1-H1.5). Their utility extends to developmental biology, cancer research, and studies of epigenetic regulation, making them pivotal in deciphering H1.0's context-dependent functions in health and disease.
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