Rabbit Monoclonal OPRD1 Antibody

The opioid receptor delta 1 (OPRD1) antibody is a research tool designed to detect and study the delta-opioid receptor (DOP), a G protein-coupled receptor (GPCR) encoded by the OPRD1 gene. DOP is one of four major opioid receptor subtypes (μ, δ, κ, and NOP) and plays critical roles in modulating pain perception, emotional responses, and reward pathways. It binds endogenous opioid peptides like enkephalins and exogenous opioids, though with lower affinity for classical opiates compared to μ-opioid receptors. OPRD1 antibodies are widely used in neuroscience, pharmacology, and pain research to investigate receptor expression, localization, and function in tissues, particularly in the central nervous system (CNS), peripheral neurons, and immune cells. These antibodies enable techniques such as Western blotting, immunohistochemistry, and flow cytometry to explore DOP's involvement in neuropsychiatric disorders (e.g., depression, addiction), chronic pain mechanisms, and immune regulation. Challenges in developing specific OPRD1 antibodies arise from structural similarities between opioid receptor subtypes and low endogenous receptor abundance. Validated antibodies help dissect DOP's signaling pathways, including Gi/o protein coupling and β-arrestin recruitment, and assess its potential as a therapeutic target for non-addictive analgesics or mood disorder treatments.