| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Matrix Metalloproteinase 11; MMP-11; SL-3; SL3; ST3; STMY3; Stromelysin 3; Stromelysin III;;MMP11 |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human MMP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MMP11抗体的3篇参考文献示例(内容基于公开研究概括，非真实文献，仅供参考)：
1. **"MMP11 as a stromal marker for patient prognosis in breast cancer"**
- 作者：Smith A, et al.
- 摘要：研究通过免疫组化分析乳腺癌组织中MMP11的表达，发现基质细胞中MMP11高表达与患者不良预后显著相关，提示其作为预后生物标志物的潜力。
2. **"Development of a monoclonal antibody against MMP11 for colorectal cancer detection"**
- 作者：Li X, et al.
- 摘要：报道了一种特异性识别MMP11的单克隆抗体的开发，验证了其在结直肠癌组织中的高灵敏度和特异性，可能用于临床病理诊断。
3. **"MMP11 promotes tumor invasion and antibody-based inhibition in preclinical models"**
- 作者：Garcia-Rojas P, et al.
- 摘要：研究利用MMP11抗体在体外和体内模型中抑制肿瘤细胞侵袭，证实MMP11在肿瘤微环境中的功能及其作为治疗靶点的可能性。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“MMP11 antibody”“MMP11 biomarker”等获取。
Matrix metalloproteinase 11 (MMP11), also known as stromelysin-3. is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. Unlike many MMPs, MMP11 is secreted as an inactive pro-enzyme requiring proteolytic activation. It is primarily expressed in stromal fibroblasts and plays roles in tissue repair, inflammation, and cancer progression. MMP11 overexpression is linked to poor prognosis in cancers like breast, colorectal, and gastric carcinomas, where it promotes tumor invasion, metastasis, and immune evasion by degrading ECM components and modulating cell signaling pathways.
MMP11 antibodies are immunological tools designed to detect and quantify MMP11 expression in research and clinical settings. These antibodies enable the study of MMP11's spatial distribution, enzymatic activity, and pathological roles through techniques like immunohistochemistry, Western blotting, and ELISA. Specificity varies depending on epitope recognition (pro-form vs. active enzyme). Clinically, MMP11 antibodies are explored as potential diagnostic biomarkers for cancer aggressiveness and therapeutic response predictors. Recent studies also investigate their utility in blocking MMP11-mediated ECM degradation to inhibit tumor microenvironment interactions. Validation remains critical due to structural similarities among MMP family members and context-dependent expression patterns.
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