| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RARalpha1; NR1B1; RAR-alpha; Retinoic acid receptor alpha; RAR;;Retinoic acid receptor alpha |
| WB Predicted band size | Calculated MW: 51 kDa ; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human Retinoic acid receptor alpha |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及Retinoic Acid Receptor alpha (RARα)抗体的文献简要信息，涵盖不同研究领域：
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1. **文献名称**：*"Retinoic Acid Receptor Alpha Mutations in Acute Promyelocytic Leukemia"*
**作者**：Lin RJ, Evans RM
**摘要**：研究RARα基因在急性早幼粒细胞白血病(APL)中的突变，利用特异性RARα抗体进行免疫沉淀和Western blot分析，揭示RARα-PML融合蛋白对细胞分化的抑制作用。
2. **文献名称**：*"RARα Controls Limb Bud Development via Orchestrating Wnt and FGF Signaling"*
**作者**：Cunningham TJ, Duester G
**摘要**：通过免疫组化(IHC)和ChIP-seq技术，结合RARα抗体，证明RARα通过调控Wnt/FGF信号通路在肢体发育中起核心作用，敲除小鼠模型中观察到肢体畸形。
3. **文献名称**：*"All-Trans Retinoic Acid Enhances RARα Antibody Efficacy in Breast Cancer Models"*
**作者**：Altucci L, Gronemeyer H
**摘要**：研究RARα激动剂与他莫昔芬联用对乳腺癌的作用，采用RARα抗体进行免疫荧光和流式细胞术，证实RARα高表达与治疗敏感性相关。
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以上文献展示了RARα抗体在白血病机制、发育生物学和癌症治疗中的典型应用，涵盖蛋白互作、基因调控及药物研究等领域。如需具体文献编号或补充，可进一步提供研究方向筛选。
The retinoic acid receptor alpha (RARα) is a member of the nuclear receptor superfamily that mediates the effects of retinoic acid (RA), a metabolite of vitamin A, by regulating gene expression. As a ligand-dependent transcription factor, RARα plays critical roles in embryonic development, cellular differentiation, proliferation, and apoptosis. It forms heterodimers with retinoid X receptors (RXRs) to bind specific DNA response elements, modulating the transcription of target genes involved in cell cycle control, immune function, and tissue homeostasis. Dysregulation of RARα is implicated in various pathologies, including acute promyelocytic leukemia (APL), where chromosomal translocations generate oncogenic fusion proteins disrupting normal RA signaling.
Antibodies targeting RARα are essential tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate RARα's role in development, cancer, and metabolic disorders. High-quality RARα antibodies exhibit specificity for distinct epitopes, enabling detection of full-length proteins, isoforms, or post-translational modifications. Their applications extend to diagnostic and therapeutic research, particularly in cancers with RARα aberrations. Validation using knockout models or siRNA knockdown ensures reliability, making these antibodies indispensable for unraveling RA signaling mechanisms and developing targeted therapies.
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