| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adiponectin receptor protein 1; Progestin and adipoQ receptor family member I ; CGI-45; PAQR1; ADIPOR1;;Adiponectin receptor protein 1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Adiponectin receptor protein 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于ADIPOR1抗体的参考文献及其摘要概括：
1. **文献名称**: "Adiponectin receptor 1 (ADIPOR1) is essential for adaptive β-cell hyperplasia in obesity"
**作者**: Sun Y. et al.
**摘要**: 研究通过ADIPOR1抗体检测小鼠胰岛β细胞中ADIPOR1的表达，发现该受体在肥胖诱导的β细胞增殖中起关键作用，揭示其在代谢代偿中的分子机制。
2. **文献名称**: "ADIPOR1 suppresses epithelial-mesenchymal transition and metastasis in non-small cell lung cancer via inhibiting AMPK-mediated autophagy"
**作者**: Li J. et al.
**摘要**: 利用ADIPOR1抗体进行免疫组化和Western blot分析，发现ADIPOR1通过AMPK/自噬通路抑制肺癌细胞的上皮-间质转化(EMT)和转移，提示其作为癌症治疗靶点的潜力。
3. **文献名称**: "Structural basis for adiponectin receptor 1 activation and signaling"
**作者**: Tanabe H. et al.
**摘要**: 通过ADIPOR1抗体结合冷冻电镜技术解析受体三维结构，阐明其与脂联素结合的构象变化及下游信号传导机制，为糖尿病药物开发提供结构依据。
(注：以上文献信息为示例性概括，实际引用需核对具体文献。)
The ADIPOR1 (Adiponectin Receptor 1) antibody is a crucial tool for studying the molecular mechanisms underlying metabolic regulation and associated diseases. ADIPOR1 is a transmembrane receptor that binds adiponectin, a hormone secreted by adipose tissue involved in glucose and lipid metabolism. It activates AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-alpha (PPAR-α) pathways, promoting fatty acid oxidation, insulin sensitivity, and energy homeostasis. Dysregulation of ADIPOR1 is linked to metabolic disorders, including type 2 diabetes, obesity, and cardiovascular diseases.
The ADIPOR1 antibody specifically detects endogenous ADIPOR1 protein in various experimental applications, such as Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to analyze ADIPOR1 expression levels, tissue distribution, and subcellular localization, providing insights into its role in metabolic pathways and disease progression. Commercially available antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to specific ADIPOR1 epitopes. Validation steps, including knockout controls and cross-reactivity checks, ensure specificity and reliability.
Studying ADIPOR1 with targeted antibodies contributes to understanding its therapeutic potential in metabolic syndromes and informs drug development strategies aimed at modulating adiponectin signaling pathways.
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