| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AGTR2; Angiotensin ii receptor type 2; Angiotensin II type-2 receptor; AT2 receptor; AT2; At2r; MRX88; Angiotensin ii at2; Angiotensin receptor 2; Type-2 angiotensin II receptor; ATGR2;;AGTR2 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human AGTR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于AGTR2抗体的参考文献示例(注：以下内容为示例，实际文献需通过学术数据库检索确认)：
1. **标题**：*Development of a Monoclonal Antibody Targeting AGTR2 for Functional Studies in Vascular Remodeling*
**作者**：Chen L, et al.
**摘要**：该研究开发了一种高特异性AGTR2单克隆抗体，验证了其在免疫印迹和免疫组织化学中的应用，并发现AGTR2在血管损伤后重塑过程中的表达上调，提示其潜在治疗价值。
2. **标题**：*AGTR2-Specific Antibody Reveals Sex-Specific Expression Patterns in Hypertensive Models*
**作者**：Rodriguez S, et al.
**摘要**：利用AGTR2抗体分析高血压动物模型，发现雄性个体中受体表达显著高于雌性，为性别差异在心血管疾病中的作用提供了新证据。
3. **标题**：*Antibody-Based Blockade of AGTR2 Attenuates Fibrosis in Diabetic Nephropathy*
**作者**：Wang Y, et al.
**摘要**：通过AGTR2抗体阻断受体活性，显著减轻糖尿病肾病模型中的肾脏纤维化，表明AGTR2可能成为延缓疾病进展的靶点。
4. **标题**：*Comparative Analysis of Commercial AGTR2 Antibodies Highlights Variability in Specificity*
**作者**：Kim H, et al.
**摘要**：评估多种市售AGTR2抗体的特异性，发现部分抗体存在交叉反应性，强调严格验证抗体在实验中的必要性。
**建议**：可通过PubMed或Google Scholar搜索“AGTR2 antibody”、“AT2 receptor antibody”等关键词，筛选近年研究以获取具体文献信息。
The angiotensin II receptor type 2 (AGTR2) is a G protein-coupled receptor that binds angiotensin II, a key peptide in the renin-angiotensin system (RAS). Primarily expressed during fetal development, AGTR2 is downregulated in most adult tissues but retains activity in organs like the kidneys, adrenal glands, brain, and reproductive systems. It counterbalances the effects of the angiotensin II type 1 receptor (AGTR1), modulating vasodilation, anti-proliferative responses, and cellular differentiation. AGTR2 activation is linked to pathways involving nitric oxide release, apoptosis, and tissue repair, with roles in cardiovascular homeostasis, renal function, and neuroprotection.
AGTR2 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both physiological and pathological contexts. They are widely used in techniques such as immunohistochemistry, Western blotting, and flow cytometry. Research highlights AGTR2's involvement in hypertension, heart failure, renal fibrosis, and neurodegenerative diseases, as well as its potential therapeutic implications. Dysregulation of AGTR2 has also been observed in cancer, influencing tumor angiogenesis and metastasis. Species-specific antibodies enable cross-disciplinary studies in human, rodent, and other models. Understanding AGTR2's dual role in tissue protection and disease progression remains a focus, driving antibody-based research to explore targeted therapies for RAS-related disorders.
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