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Rabbit Monoclonal AKAP14 Antibody

  • 中文名： AKAP14抗体
  • 别    名： A-kinase anchor protein 14; A-kinase anchor protein 14; A-kinase anchor protein 28 kDa; AKAP14; AKAP28;;AKAP 14
货号: IPDX17312
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesA-kinase anchor protein 14; A-kinase anchor protein 14; A-kinase anchor protein 28 kDa; AKAP14; AKAP28;;AKAP 14
WB Predicted band size23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human AKAP 14
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于AKAP14抗体的3篇参考文献示例(注：内容为模拟生成，仅供参考)：

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1. **文献名称**：*A-Kinase Anchoring Protein 14 (AKAP14) is essential for sperm motility via PKA-RIIα regulatory complex localization*

**作者**：Brown, K.A., et al.

**摘要**：本研究利用特异性AKAP14抗体，揭示了AKAP14通过锚定PKA-RIIα调控复合体至精子鞭毛轴丝，维持精子超活化运动的功能。Western blot及免疫荧光证实抗体特异性，并发现AKAP14缺失导致小鼠生育力下降。

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2. **文献名称**：*Generation and characterization of monoclonal antibodies targeting human AKAP14 for cilia-related studies*

**作者**：Smith, J.P., et al.

**摘要**：报道了两种高特异性抗人AKAP14单克隆抗体的开发，验证其在免疫沉淀(IP)和免疫组化(IHC)中的应用。研究显示AKAP14在呼吸道纤毛上皮细胞中高表达，提示其可能参与纤毛运动调控。

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3. **文献名称**：*AKAP14 expression correlates with poor prognosis in testicular germ cell tumors*

**作者**：Lee, H., & Tanaka, Y.

**摘要**：通过AKAP14抗体对临床样本分析，发现AKAP14在睾丸生殖细胞肿瘤中异常高表达，并与肿瘤侵袭性相关。研究提示AKAP14可能作为潜在生物标志物或治疗靶点。

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(注：若需真实文献，建议通过PubMed或Google Scholar搜索“AKAP14 antibody”获取最新研究。)

背景信息

The AKAP14 antibody is a tool used to study the A-kinase anchoring protein 14 (AKAP14), a member of the AKAP family that localizes protein kinase A (PKA) to specific cellular compartments. AKAP14. also known as AKAP28. is involved in anchoring PKA to regulatory sites, facilitating cAMP-dependent signaling pathways. It is predominantly expressed in tissues like testes, ciliated epithelia, and skeletal muscle, suggesting roles in sperm motility, ciliary function, and muscle contraction. The antibody detects AKAP14 in applications such as Western blotting, immunofluorescence, or immunoprecipitation, aiding in the investigation of its spatial-temporal regulation and interactions with PKA isoforms or other signaling components. Researchers utilize it to explore AKAP14's involvement in physiological processes (e.g., spermatogenesis, airway cilia activity) or pathological conditions (e.g., infertility, respiratory disorders). Validation often includes testing in AKAP14-knockout models or siRNA-treated cells to confirm specificity. Commercial antibodies may target specific epitopes, such as the N-terminal or central regions, and cross-reactivity with other AKAPs should be assessed. Its utility extends to both basic research and clinical studies, particularly in reproductive health and ciliopathy-related diseases.

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