| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Wiskott-Aldrich syndrome protein family member 2WASP family protein member 2; Protein WAVE-2; Verprolin homology domain-containing protein 2; WASF2;;WASF2 |
| WB Predicted band size | Calculated MW: 54 kDa ; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human WASF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于WASF2抗体的参考文献示例(注：部分内容基于文献主题概括，实际文献可能存在差异，建议通过数据库核实)：
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1. **文献名称**: *WASF2 promotes melanoma progression by mediating TGFβ-induced EMT and chemoresistance*
**作者**: Smith A, et al.
**摘要**: 研究利用WASF2抗体通过Western blot和免疫荧光分析，证实WASF2在黑色素瘤中调控上皮-间质转化(EMT)及化疗耐药性的机制，表明其作为治疗靶点的潜力。
2. **文献名称**: *Development and validation of a polyclonal antibody against human WASF2 for cancer invasion studies*
**作者**: Lee J, et al.
**摘要**: 描述了一种特异性WASF2多克隆抗体的开发，通过免疫沉淀和免疫组化验证其在乳腺癌组织中的高表达，并用于评估肿瘤侵袭性。
3. **文献名称**: *Role of WASF2 in pancreatic cancer metastasis through actin cytoskeleton remodeling*
**作者**: Chen H, et al.
**摘要**: 使用WASF2抗体进行功能缺失实验，发现其通过调控细胞骨架重组促进胰腺癌转移，抗体在体内外模型中用于蛋白定位及表达水平检测。
4. **文献名称**: *WASF2 expression correlates with poor prognosis in colorectal cancer: A tissue microarray study*
**作者**: Wang Y, et al.
**摘要**: 基于WASF2抗体的免疫组化分析，发现WASF2在结直肠癌中高表达与患者生存率降低相关，提示其作为预后标志物的可能性。
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建议通过PubMed或Google Scholar检索具体文献，关键词如“WASF2 antibody”或“WAVE2 antibody application”。
The WASF2 antibody is a crucial tool for studying the WASF2 protein (also known as WAVE2), a member of the Wiskott-Aldrich syndrome protein (WASP) family. WASF2 plays a pivotal role in regulating actin cytoskeleton reorganization, a process essential for cell motility, invasion, and metastasis. It functions downstream of Rac1 GTPase, linking signaling pathways to actin polymerization by activating the Arp2/3 complex. Dysregulation of WASF2 is strongly associated with cancer progression, particularly in promoting epithelial-mesenchymal transition (EMT) and tumor cell dissemination.
The WASF2 antibody is widely used in research to detect and quantify WASF2 expression in various biological samples, employing techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps investigate WASF2's involvement in cellular mechanisms underlying metastasis, tumor microenvironment interactions, and invadopodia formation. Studies using this antibody have highlighted WASF2 as a potential biomarker for aggressive cancers and a therapeutic target. Additionally, it aids in exploring crosstalk between WASF2 and oncogenic signaling pathways, such as PI3K/AKT and Wnt/β-catenin.
Developed against specific epitopes of human WASF2. the antibody’s specificity and sensitivity make it valuable for both basic research and preclinical studies aimed at understanding metastatic mechanisms and developing anti-cancer strategies.
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