| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | annexin 14; annexin A10; annexin-14; ANX10; ANX14;;Annexin A10 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Annexin A10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是与AnnexinA10抗体相关的3篇文献示例，按研究领域和内容概括整理：
1. **文献名称**：*"Annexin A10 is a marker for gastric adenocarcinomas with pancreatic lineage"*
**作者**：Moriyama T, et al.
**摘要**：通过免疫组化分析，研究发现AnnexinA10在胃胰型腺癌中特异性高表达，提示其可作为该亚型胃癌的潜在诊断标志物。
2. **文献名称**：*"Annexin A10 expression correlates with serrated pathway features in colorectal carcinomas with microsatellite instability"*
**作者**：Kang HS, et al.
**摘要**：利用AnnexinA10抗体检测结直肠癌组织，发现其表达与微卫星不稳定(MSI)亚型及锯齿状通路相关，可能参与肿瘤分子分型。
3. **文献名称**：*"Antibody validation of Annexin A10 in pancreatic ductal adenocarcinoma reveals its role in tumor differentiation"*
**作者**：Hansen K, et al.
**摘要**：通过Western blot和免疫组化验证AnnexinA10抗体特异性，发现其在胰腺导管腺癌中的表达与肿瘤分化程度相关，可能影响患者预后。
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**备注**：以上文献为示例，实际检索时建议通过PubMed或Web of Science等数据库输入“AnnexinA10 antibody”或“AnnexinA10 immunohistochemistry”等关键词获取最新研究。部分研究可能侧重抗体应用(如诊断分型)，另一些可能侧重机制(如信号通路调控)。
Annexin A10 (ANXA10) is a member of the annexin family, calcium-dependent phospholipid-binding proteins implicated in diverse cellular processes, including membrane trafficking, signal transduction, and apoptosis. Unlike other annexins, ANXA10 exhibits tissue-specific expression, predominantly localized in the gastric mucosa, skin, and gastrointestinal tract. Its biological roles remain less characterized but are thought to involve cell differentiation and tumorigenesis regulation.
ANXA10 antibodies are immunodetection tools targeting this protein, widely used in research to study its expression, localization, and function. These antibodies are critical in techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). Notably, ANXA10 has gained attention as a potential biomarker in oncology. Studies link its overexpression to specific cancers, particularly gastric and colorectal adenocarcinomas, where it may serve as a diagnostic or prognostic indicator. For example, ANXA10 is highly expressed in a subset of gastric cancers with poor differentiation, suggesting its utility in tumor subtyping.
Commercially available ANXA10 antibodies are typically monoclonal or polyclonal, validated for specificity and sensitivity across human and murine samples. Researchers must optimize protocols due to potential cross-reactivity with other annexins or tissue-specific isoforms. Recent investigations also explore ANXA10's role in drug resistance and its interaction with signaling pathways like Wnt/β-catenin, highlighting its therapeutic relevance.
In summary, ANXA10 antibodies are vital for elucidating the protein’s pathophysiological roles, particularly in cancer biology, while advancing diagnostic and therapeutic strategies.
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