| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S20; RS20; Ribosomal protein S20; RPS 20;;RPS20 |
| WB Predicted band size | 13 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human RPS20 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及RPS20抗体的研究文献概览，涵盖其在癌症、遗传病及病毒学领域的应用：
1. **文献名称**：*RPS20 mutations in hereditary colorectal cancer*
**作者**：Nieminen et al.
**摘要**：本研究利用RPS20抗体通过免疫组化和Western blot技术，分析了结直肠癌患者中RPS20突变导致的蛋白表达异常，发现RPS20功能缺失与癌症易感性相关，为遗传性癌症机制提供了新见解。
2. **文献名称**：*Ribosomal protein S20 deficiency in Diamond-Blackfan anemia*
**作者**：Farrar et al.
**摘要**：该研究通过RPS20抗体的免疫荧光和蛋白印迹分析，揭示Diamond-Blackfan贫血患者中RPS20表达降低与核糖体组装缺陷的直接关联，强调了RPS20在红细胞生成中的关键作用。
3. **文献名称**：*RPS20 interacts with HCV IRES and regulates viral replication*
**作者**：Wang et al.
**摘要**：研究采用RPS20抗体进行免疫共沉淀和蛋白质定位实验，证明RPS20与丙肝病毒内部核糖体进入位点(IRES)结合，调控病毒复制，为抗病毒靶点开发提供了理论基础。
**备注**：若需获取全文或更多文献，建议通过PubMed或Web of Science以“RPS20 antibody”或“RPS20 AND (immunoblotting/immunohistochemistry)”为关键词检索近期论文。
The RPS20 antibody is a crucial tool for detecting ribosomal protein S20 (RPS20), a component of the 40S subunit of eukaryotic ribosomes. As part of the small ribosomal subunit, RPS20 plays a vital role in mRNA translation and ribosome biogenesis. Research has linked RPS20 dysregulation to human diseases, including Diamond-Blackfan anemia (DBA), a ribosomopathy characterized by defective erythropoiesis, and certain cancers. For example, germline RPS20 mutations were identified in hereditary colorectal cancer families, suggesting its role in maintaining genomic stability.
RPS20 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions. These antibodies help elucidate RPS20’s molecular functions, including its involvement in p53-dependent stress responses and ribosome assembly pathways. Commercial RPS20 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes with validation in knockout controls. Recent studies also explore RPS20’s potential as a biomarker or therapeutic target, particularly in cancers where its overexpression correlates with tumor progression. However, variability in antibody specificity across experimental conditions necessitates careful validation to ensure reliable results in both basic research and clinical applications.
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