| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RDX; Radixin; Protein roadkill; HIB; ESP10; DFNB24; RADI;;Radixin |
| WB Predicted band size | Calculated MW: 69 kDa ; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Radixin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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1. **"Radixin regulates cell migration and invasion by modulating Rho GTPase activity in hepatocellular carcinoma"**
- 作者：Li, Y.; Yang, X.; Wang, H.
- 摘要：研究通过Radixin抗体检测肝癌细胞，发现其通过调控Rho GTPase活性影响肿瘤细胞的迁移和侵袭能力，提示其在癌症转移中的作用。
2. **"Radixin-specific monoclonal antibody reveals dynamic localization in stereocilia of auditory hair cells"**
- 作者：Pataky, F.; Müller, U.
- 摘要：利用Radixin特异性抗体进行免疫荧光，揭示其在内耳毛细胞静纤毛中的动态分布，表明其对听觉机械转导的关键作用。
3. **"Characterization of a novel anti-radixin antibody for super-resolution imaging of epithelial tight junctions"**
- 作者：Suzuki, A.; Ohno, S.
- 摘要：开发并验证一种新型Radixin抗体，成功用于超分辨率显微镜技术，解析Radixin在上皮细胞紧密连接中的纳米级空间定位。
4. **"Radixin deficiency disrupts intestinal barrier integrity via dysregulation of actin cytoskeleton in inflammatory bowel disease"**
- 作者：Zhang, L.; Chen, J.
- 摘要：通过Radixin抗体检测发现，Radixin缺失导致肠道上皮细胞肌动蛋白骨架紊乱，加剧炎症性肠病的屏障功能障碍。
(注：上述文献为示例性内容，实际引用时请核实真实存在的论文信息。)
Radixin is a cytoskeletal protein belonging to the ERM (Ezrin, Radixin, Moesin) family, which plays a critical role in linking the plasma membrane to the actin cytoskeleton, maintaining cell shape, and regulating cell adhesion and motility. Radixin antibodies are essential tools in biomedical research for detecting and studying the expression, localization, and function of Radixin in various tissues and cellular contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore Radixin's involvement in dynamic cellular processes, including membrane protrusion formation, cell polarization, and junctional complex assembly.
Radixin is particularly abundant in liver hepatocytes and epithelial cells, where it stabilizes specialized membrane structures like microvilli. Studies using Radixin-specific antibodies have revealed its role in liver regeneration, bile canalicular formation, and maintenance of epithelial barrier integrity. Dysregulation of Radixin expression has been implicated in pathological conditions, including liver disorders and metastatic cancers, making these antibodies valuable for investigating disease mechanisms. Recent research also highlights Radixin's interaction with signaling molecules like Rho GTPases, underscoring its importance in cytoskeletal remodeling pathways. Validated Radixin antibodies enable precise detection of post-translational modifications (e.g., phosphorylation) that regulate its activity, aiding both basic research and potential clinical biomarker development.
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