| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FTH1; Ferritin heavy chain; Ferritin heavy polypeptide 1; FHC; FTHL6; PIG15; PLIF; FTH;;Ferritin |
| WB Predicted band size | Calculated MW: 21,20 kDa ; Observed MW: 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Ferritin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于铁蛋白(Ferritin)抗体的3篇代表性文献摘要(注：内容为示例性概括，非真实文献)：
1. **《Autoantibodies against Ferritin in Systemic Lupus Erythematosus: Clinical Correlations》**
- 作者：Smith A, et al.
- 摘要：本研究探讨系统性红斑狼疮(SLE)患者血清中铁蛋白自身抗体的存在及其与疾病活动的关联。通过ELISA检测发现，约30%的SLE患者存在抗铁蛋白抗体，且抗体水平与疾病活动指数(SLEDAI)呈正相关，提示其可能参与炎症调控。
2. **《Development of a High-Sensitivity Monoclonal Antibody for Ferritin Quantification in Human Serum》**
- 作者：Zhang L, et al.
- 摘要：研究团队开发了一种针对人血清铁蛋白的高灵敏度单克隆抗体，并建立了新型化学发光检测法。该抗体特异性识别铁蛋白轻链(L-Ferritin)，检测下限达0.1 ng/mL，为缺铁性贫血的早期诊断提供了可靠工具。
3. **《Ferritin Antibody-Based Nanoprobe for Targeted Cancer Imaging》**
- 作者：Wang Y, et al.
- 摘要：利用铁蛋白抗体的靶向性，设计了一种负载造影剂的纳米探针，可特异性结合肿瘤细胞表面过表达的膜铁蛋白。动物实验显示，该探针显著提高了肝癌模型小鼠的MRI成像对比度，具有潜在诊疗一体化应用价值。
Ferritin antibodies are immunological tools designed to target ferritin, a ubiquitous iron-storage protein critical for maintaining cellular iron homeostasis. Composed of heavy (H) and light (L) chain subunits, ferritin sequesters excess iron in a non-toxic, bioavailable form, protecting cells from oxidative damage while regulating iron release for metabolic processes. Antibodies against ferritin are widely used in research and diagnostics to quantify ferritin levels, which serve as biomarkers for iron deficiency, iron overload disorders (e.g., hemochromatosis), and inflammatory conditions, as ferritin synthesis increases during acute-phase responses.
These antibodies are typically raised in immunized animals (e.g., rabbits, mice) using purified ferritin or recombinant subunits as antigens. Both polyclonal and monoclonal formats exist, with monoclonal antibodies offering higher specificity for distinguishing H- and L-chain isoforms. Applications include Western blotting, immunohistochemistry, and ELISA to assess tissue iron distribution, diagnose diseases, or study ferritin’s role in pathologies like neurodegeneration or cancer. Some autoantibodies against ferritin have also been reported in autoimmune contexts, though their clinical significance remains under investigation. Overall, ferritin antibodies are indispensable for exploring iron metabolism and related disorders.
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