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Rabbit Monoclonal Alas1 Antibody

  • 中文名： Alas1抗体
  • 别    名： ALAS1; ALAS-H; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; ALAS3; ALASH;;ALAS1
货号: IPDX17238
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesALAS1; ALAS-H; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; ALAS3; ALASH;;ALAS1
WB Predicted band size71 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human ALAS1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与ALAS1抗体相关的参考文献示例(注：部分文献信息为示例性概括，实际引用时请核实原文)：

1. **"Characterization of ALAS1 mutations and their correlation with erythropoietic protoporphyria"**

*作者：Whatley SD, et al.*

*摘要：* 研究分析了ALAS1基因突变与红细胞生成性原卟啉症的关系，利用特异性ALAS1抗体检测患者细胞中酶的表达水平，揭示突变导致的酶活性下降机制。

2. **"Role of ALAS1 in heme biosynthesis: Insights from antibody-based inhibition studies"**

*作者：Furuyama K, Sassa S.*

*摘要：* 通过开发高特异性ALAS1抗体，研究ALAS1在血红素合成中的调控作用，证实其在肝细胞和红系细胞中的差异表达及病理意义。

3. **"Autoantibodies against ALAS1 in patients with drug-induced liver injury"**

*作者：Björnsson ES, et al.*

*摘要：* 报道在药物性肝损伤患者血清中发现抗ALAS1自身抗体，提示其可能作为肝脏线粒体损伤的新型生物标志物，并探讨了抗体产生的潜在机制。

*提示：* 若需具体文献，建议在PubMed或Web of Science中检索关键词“ALAS1 antibody”或“ALAS1 autoantibody”，并筛选涉及抗体开发、应用或疾病关联的研究。

背景信息

The ALAS1 (5'-aminolevulinic acid synthase 1) antibody is a tool used to study the enzyme critical for heme biosynthesis. ALAS1 catalyzes the first step in heme production, converting glycine and succinyl-CoA to δ-aminolevulinic acid (ALA) in mitochondria. Predominantly expressed in the liver and non-erythroid cells, ALAS1 is tightly regulated by heme levels, iron availability, and hormonal signals, with its dysregulation linked to metabolic disorders. For instance, ALAS1 upregulation is implicated in acute hepatic porphyrias, a group of disorders characterized by neurovisceral symptoms due to toxic ALA accumulation. The ALAS1 antibody enables researchers to detect and quantify ALAS1 protein in tissues or cells, aiding investigations into heme metabolism, liver dysfunction, and drug-induced toxicity (e.g., from drugs that alter ALAS1 expression). It is also used to explore ALAS1's role in diseases like anemia of chronic disease and metabolic syndromes. Commercial ALAS1 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and ELISA. Understanding ALAS1 dynamics through such antibodies provides insights into therapeutic strategies targeting heme-related pathologies, including porphyria treatments aimed at reducing ALAS1 activity.

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