| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RPS3; 40S ribosomal protein S3;;RPS3 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human RPS3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于RPS3抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：*RPS3 modulates oxidative stress-induced apoptosis via interaction with Ref-1*
**作者**：Kim J, et al.
**摘要**：研究利用RPS3抗体通过免疫沉淀和Western blot技术，揭示了RPS3通过与抗氧化蛋白Ref-1相互作用，调节细胞在氧化应激下的存活机制。抑制RPS3会增加DNA损伤和细胞凋亡。
2. **文献名称**：*High expression of RPS3 predicts poor prognosis in colorectal cancer*
**作者**：Zhang L, et al.
**摘要**：通过免疫组化(使用RPS3特异性抗体)分析结直肠癌组织，发现RPS3高表达与肿瘤侵袭性及患者生存率降低相关，提示其作为潜在预后标志物的可能性。
3. **文献名称**：*RPS3 antibody reveals its dual role in ribosome biogenesis and DNA repair*
**作者**：Jung H, et al.
**摘要**：该研究结合RPS3抗体的免疫荧光和ChIP实验，证明RPS3不仅参与核糖体组装，还通过结合损伤DNA位点调控修复通路，影响基因组稳定性。
4. **文献名称**：*RPS3 aggregation in neurodegenerative disorders: Insights from antibody-based assays*
**作者**：Smith R, et al.
**摘要**：利用RPS3抗体的ELISA和免疫印迹技术，发现阿尔茨海默病患者脑组织中RPS3异常聚集，可能与tau蛋白病理相关，为神经退行机制提供新视角。
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**注意**：以上文献为示例性内容，实际研究中需通过学术数据库(如PubMed、Web of Science)检索真实文献。
The RPS3 antibody targets the 40S ribosomal protein S3 (RPS3), a component of the small ribosomal subunit involved in mRNA translation. Beyond its canonical role in protein synthesis, RPS3 exhibits non-ribosomal functions, including participation in DNA damage repair, NF-κB signaling modulation, and regulation of apoptosis. These multifunctional properties link RPS3 to critical cellular processes such as oxidative stress responses, inflammation, and cancer progression. Dysregulation of RPS3 expression or activity has been observed in malignancies like colorectal cancer and glioblastoma, where it may influence tumorigenesis, drug resistance, or metastatic potential.
RPS3 antibodies are widely used in research to study its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Specific antibodies may distinguish between post-translationally modified forms (e.g., phosphorylated RPS3) or detect isoform-specific variants. Polyclonal antibodies often provide broader epitope recognition, while monoclonal versions offer higher specificity. Researchers frequently employ these tools to investigate RPS3’s dual roles in ribosomal biology and stress signaling pathways, particularly in contexts of chemotherapy resistance, neurodegenerative protein aggregation, and viral infection responses. Proper validation using knockout controls remains essential due to potential cross-reactivity with other ribosomal proteins.
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